The 14-3-3 cancer connection

被引：357
|
作者：
Hermeking, H [1 ]
机构：
[1] Max Planck Inst Biochem, D-82152 Martinsried, Germany
来源：
NATURE REVIEWS CANCER | 2003年 / 3卷 / 12期
关键词：
D O I：
10.1038/nrc1230
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
14-3-3 proteins regulate many cellular processes that are important in cancer biology, such as apoptosis and cell-cycle checkpoints. There are seven human 14-3-3 genes and one of these, 14-3-3sigma, has been directly implicated in the aetiology of human cancer. Loss of 14-3-3sigma expression sensitizes cancer cells to conventional anticancer agents, so its inhibition could be exploited for therapeutic purposes. Interference with 14-3-3 function as a therapeutic approach is being evaluated at present and, in the case of UCN-01, is under clinical investigation.
引用
收藏
页码：931 / 943
页数：13
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