Hypoxia and Hypoxia-Inducible Factors in Lymphedema

被引：6

作者：

Jiang, Xinguo ^{[1
,2
]}

Tian, Wen ^{[1
,2
]}

Kim, Dongeon ^{[1
,2
]}

McQuiston, Alexander S. ^{[1
,2
]}

Vinh, Ryan ^{[1
,2
]}

Rockson, Stanley G. ^{[2
]}

Semenza, Gregg L. ^{[3
,4
,5
,6
,7
,8
]}

Nicolls, Mark R. ^{[1
,2
]}

机构：

[1] VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA

[2] Stanford Univ, Sch Med, Stanford, CA 94305 USA

[3] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Radiat Oncol, Baltimore, MD USA

[7] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

[8] Johns Hopkins Univ, Sch Med, Inst Cell Engn, McKusick Nathans Inst Genet Med,Vasc Program, Baltimore, MD USA

来源：

FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷

关键词：

HIF; lymphedema; inflammation; lymphangiogensis; hypoxia; ADIPOSE-TISSUE HYPOXIA; MYOFIBROBLAST DIFFERENTIATION; LYMPHATIC DYSFUNCTION; SECONDARY LYMPHEDEMA; IMMUNE PROTEINS; MACROPHAGES; INFLAMMATION; FIBROSIS; LYMPHANGIOGENESIS; OBESITY;

D O I：

10.3389/fphar.2022.851057

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete. Currently, there is no approved pharmacological therapy for this debilitating disease. Hypoxia is a recognized feature of inflammation, obesity, and fibrosis. Understanding hypoxia-regulated pathways in lymphedema may provide new insights into the pathobiology of this chronic disorder and help develop new medicinal treatments.

引用

页数：7

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