Molecular-genetic analysis of the left ventricular hypertrophy

Hypertrophy of the left ventricular myocardium increases risk of cardiovascular complications by several times. Diagnostic reliability of genetic markers for assessment of degree of formation of pathological states is comparable with that of clinical symptoms. This stimulates the search of novel clinical-genetic interrelationships for determination of risk of a disease and its prognosis. Associations of 3 polymorphic markers: insertion-deletion (I/D) of angiotesin converting enzyme gene, T174M of angiotesinogen gene and VNTR in endothelial NO synthase (eNOS) gene (A and B alleles) with echocardiographical parameters of left ventricular myocardial mass has been assessed in 98 patients with essential hypertension and 12 patients with idiopathic hypertrophic cardiomyopathy. D-allele of angiotesin converting enzyme gene and A-allele of eNOS gene are associated with higher values of left ventricular myocardial mass both in essential hypertension and hypertrophic cardiomyopathy. A suggestion has made that mechanisms of development of left ventricular hyperterophy in these groups of patients are similar.