Acid-degradable core-crosslinked micelles prepared from thermosensitive glycopolymers synthesized via RAFT polymerization

被引：126

作者：

Zhang, Ling ^{[1
,2
]}

Bernard, Julien ^{[1
,3
,4
,5
]}

Davis, Thomas P.

Barner-Kowollik, Christopher ^{[1
]}

Stenzel, Martina H. ^{[1
]}

机构：

[1] Univ New S Wales, Sch Chem Sci & Engn, CAMD, Sydney, NSW 2052, Australia

[2] CRC P, Notting Hill, Vic 3168, Australia

[3] Univ Lyon, F-69003 Lyon, France

[4] Inst Natl Sci Appl, IMP LMM, F-69621 Villeurbanne, France

[5] CNRS, UMR 5223, F-69621 Villeurbanne, France

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2008年 / 29卷 / 02期

关键词：

acid-degradable; crosslinked micelle; glycopolymer; reversible addition fragmentation chain transfer (RAFT); stimuli-sensitive polymers;

D O I：

10.1002/marc.200700663

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A thermoresponsive block copolymer, namely poly(acryloyl glucosamine)-block-poly(N-isopropylacryamide) (PAGA(180)-b-PNIPAAM(350))was simultaneously self-assembled and cross-linked in aqueous medium via RAFT polymerization at 60 degrees C to afford core-crosslinked micelles exhibiting a glycopolymer corona and a PNIPAAM stimuli-responsive core. An acid-labile crosslinking agent, 3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5]-undecane, was employed to generate thermosensitive and acid-degradable core-shell nanoparticles. Stable against crosslinked micelles readily hydrolyzed block copolymers at lower pH (30 min and 12 h respectively pH = 2 and 4).

引用

页码：123 / 129

页数：7

共 16 条

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[8] Facile preparation of core-crosslinked micelles from azide-containing thermoresponsive double hydrophilic diblock copolymer via click chemistry
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[9] Polymeric core-crosslinked particles prepared via a nanoemulsion-mediated process: from particle design and structural characterization to in vivo behavior in chemotherapy
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[J]. Polymer Journal, 2023, 55 : 921 - 933
[10] Polymeric core-crosslinked particles prepared via a nanoemulsion-mediated process: from particle design and structural characterization to in vivo behavior in chemotherapy
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[J]. POLYMER JOURNAL, 2023, 55 (09) : 921 - 933

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