Experimental Infection of Brazilian Free-Tailed Bats (Tadarida brasiliensis) with Two Strains of SARS-CoV-2

被引:7
|
作者
Bosco-Lauth, Angela M. [1 ]
Porter, Stephanie M. [2 ]
Fox, Karen A. [3 ]
Wood, Mary E. [3 ]
Neubaum, Daniel [3 ]
Quilici, Marissa [1 ]
机构
[1] Colorado State Univ, Dept BioMed Sciences, Ft Collins, CO 80523 USA
[2] Natl Wildlife Res Ctr, US Dept Agr, Anim & Plant Hlth Inspection Serv Wildlife Serv, Ft Collins, CO 80523 USA
[3] Colorado Parks & Wildlife, Ft Collins, CO 80523 USA
来源
VIRUSES-BASEL | 2022年 / 14卷 / 08期
关键词
Brazilian free-tailed bat; Tadarida brasiliensis; SARS-CoV-2; infection;
D O I
10.3390/v14081809
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is presumed to have originated from wildlife and shares homology with other bat coronaviruses. Determining the susceptibility of North American bat species to SARS-CoV-2 is of utmost importance for making decisions regarding wildlife management, public health, and conservation. In this study, Brazilian free-tailed bats (Tadarida brasiliensis) were experimentally infected with two strains of SARS-CoV-2 (parental WA01 and Delta variant), evaluated for clinical disease, sampled for viral shedding and antibody production, and analyzed for pathology. None of the bats (n = 18) developed clinical disease associated with infection, shed infectious virus, or developed histopathological lesions associated with SARS-CoV-2 infection. All bats had low levels of viral RNA in oral swabs, six bats had low levels of viral RNA present in the lungs during acute infection, and one of the four bats that were maintained until 28 days post-infection developed a neutralizing antibody response. These findings suggest that Brazilian free-tailed bats are permissive to infection by SARS-CoV-2, but they are unlikely to contribute to environmental maintenance or transmission.
引用
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页数:8
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