Acute effects of smoked marijuana in marijuana smokers at clinical high-risk for psychosis: A preliminary study

被引：20

作者：

Vadhan, Nehal P. ^{[1
,2
,3
]}

Corcoran, Cheryl M. ^{[4
,5
]}

Bedi, Gill ^{[4
,5
]}

Keilp, John G. ^{[4
,5
]}

Haney, Margaret ^{[4
,5
]}

机构：

[1] Hofstra Northwell Sch Med, Dept Psychiat, 1010 Northern Blvd,Suite 311, Great Neck, NY 11021 USA

[2] Hofstra Northwell Sch Med, Dept Mol Med, 1010 Northern Blvd,Suite 311, Great Neck, NY 11021 USA

[3] Feinstein Inst Med Res, Ctr Psychiat Neurosci, 1010 Northern Blvd,Suite 311, Great Neck, NY 11021 USA

[4] Columbia Univ, Dept Psychiat, Med Ctr, New York, NY USA

[5] New York State Psychiat Inst & Hosp, New York, NY 10032 USA

来源：

PSYCHIATRY RESEARCH | 2017年 / 257卷

关键词：

Cannabis; Prodromal psychosis; Ultra high-risk; ULTRA-HIGH RISK; CANNABIS USE; DELTA-9-TETRAHYDROCANNABINOL; SCHIZOPHRENIA; TRANSITION; PEOPLE;

D O I：

10.1016/j.psychres.2017.07.070

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Marijuana use is associated with psychosis, but its effects are understudied in individuals with preexisting risk for psychotic disorders. This preliminary study examined the acute psychological and physiological effects of smoked marijuana (0.0% or 5.5% 49-THC) in marijuana users at clinical high-risk (CHR; n = 6) to develop a psychotic disorder, and those not at risk (n = 6), under controlled laboratory conditions. CHR marijuana users exhibited temporary increases in psychotic-like states and decreases in neurocognitive performance during marijuana intoxication but control marijuana smokers did not. These findings, if replicated, may support a psychotogenic role for marijuana in CHR individuals.

引用

页码：372 / 374

页数：3

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