Transformation of Catalytic Characteristics of Cerebral Monoamine Oxidases in Experimental Posttraumatic Stress Disorders

被引：4
|
作者：
Kolesnikova, L. I. [1 ]
Popova, A. S. [1 ]
Deev, R. V. [2 ]
Sinitskii, A. I. [2 ]
Krupitskaya, L. I. [1 ]
机构：
[1] Russian Acad Med Sci, Siberian Div, Res Ctr Family Hlth & Human Reprod Problems, Irkutsk, Russia
[2] South Ural State Med Univ, Minist Hlth Russian Federat, Chelyabinsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 158卷 / 05期
关键词：
monoamine oxidase; posttraumatic stress disorder; free radical oxidation;
D O I：
10.1007/s10517-015-2826-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the contribution of the transformation of the catalytic properties of cerebral monoamine oxidase in the development of behavioral disorders during stress. Monoamine oxidase activities and catalytic characteristics, LPO intensity, and oxidative modification of proteins in suspension of the brain mitochondria were evaluated over the course of experimental posttraumatic stress disorder. The detected shifts were comparable with the results of neuroethologic testing. The development of behavioral disorders presented by low exploratory activity and high anxiety was associated with transformation of catalytic characteristics of cerebral monoamine oxidases, associated with the development of oxidative stress with predominant intensification of metal-catalyzed protein oxidation.
引用
收藏
页码：641 / 643
页数：3
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