Overcoming Chemotherapy Resistance in SCLC

被引：64
|
作者：
Herzog, Brett H. [1 ,2 ]
Devarakonda, Siddhartha [1 ,2 ]
Govindan, Ramaswamy [1 ,2 ]
机构：
[1] Washington Univ, Dept Med, Div Oncol, Sch Med, St Louis, MO USA
[2] Washington Univ, Alvin J Siteman Canc Ctr, St Louis, MO USA
来源：
JOURNAL OF THORACIC ONCOLOGY | 2021年 / 16卷 / 12期
基金：
美国国家卫生研究院;
关键词：
Small cell lung cancer; SCLC; Chemotherapy; Resistance; Chemoresistance; CELL LUNG-CANCER; GENE-EXPRESSION; MULTIDRUG-RESISTANCE; DRUG-RESISTANCE; PROMOTES CHEMORESISTANCE; THERAPEUTIC TARGETS; LSD1; INHIBITORS; P-GLYCOPROTEIN; GROWTH; TWIST1;
D O I：
10.1016/j.jtho.2021.07.018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
SCLC is an aggressive form of lung cancer with a very poor prognosis. Although SCLC initially responds very well to platinum-based chemotherapy, it eventually recurs and at recurrence is nearly universally resistant to therapy. In light of the recent advances in understanding regarding the biology of SCLC, we review findings related to SCLC chemotherapy resistance. We discuss the potential clinical implications of recent preclinical discoveries in altered signaling pathways, transcriptional landscapes, metabolic vulnerabilities, and the tumor microenvironment. (c) 2021 Published by Elsevier Inc. on behalf of International Association for the Study of Lung Cancer.
引用
收藏
页码：2002 / 2015
页数：14
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