Promotion of seminomatous tumors by targeted overexpression of glial cell line-derived neurotrophic factor in mouse testis

被引：1
|
作者：
Meng, XJ
de Rooij, DG
Westerdahl, K
Saarma, M
Sariola, H
机构：
[1] Univ Helsinki, Inst Biotechnol, Viikki Bioctr, Dev Biol Program, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Inst Biotechnol, Viikki Bioctr, Mol Neurobiol Res Program, FIN-00014 Helsinki, Finland
[3] Univ Helsinki, HUCS Diagnost, FIN-00014 Helsinki, Finland
[4] Univ Helsinki, Dept Biomed, FIN-00014 Helsinki, Finland
[5] Univ Utrecht, Med Ctr, Dept Cell Biol, NL-3584 CX Utrecht, Netherlands
来源：
CANCER RESEARCH | 2001年 / 61卷 / 08期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We show with transgenic mice that targeted overexpression of glial cell line-derived neurotrophic factor (GDNF) in undifferentiated spermatogonia promotes malignant testicular tumors, which express germ-cell markers. The tumors are invasive and contain aneuploid cells, but no distant metastases have been found. By several histological, molecular, and histochemical characteristics, the GDNF-induced tumors mimic classic seminomas in men, representing a useful experimental model for testicular germ-cell tumors. The data also show that a deregulated stimulation of a normal proto-oncogene by its ligand can be an initiative event in carcinogenesis.
引用
收藏
页码：3267 / 3271
页数：5
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