Cobalt(II)-Catalyzed Oxidative C-H Alkenylations: Regio- and Site-Selective Access to Isoindolin-1-one

被引：154
|
作者：
Ma, Wenbo [1 ]
Ackermann, Lutz [1 ]
机构：
[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany
来源：
ACS CATALYSIS | 2015年 / 5卷 / 05期
基金：
欧洲研究理事会;
关键词：
C-H activation; alkenylation; cobalt; mechanism; oxidative annulation; CATALYZED DIRECT ARYLATION; BOND FORMATION; CARBON-HYDROGEN; HG2+ IONS; COBALT; PALLADIUM; ALKYNES; HYDROARYLATION; FUNCTIONALIZATIONS; FLUORESCENT;
D O I：
10.1021/acscatal.5b00322
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Isoindolinone derivatives were prepared in a step-economical fashion by a C-H/N-H functionalization process with a catalytic system composed of Co(OAc)(2) and Mn(OAc)(2) or AgOPiv. The oxidative annulation by benzamides occurred efficiently with differently substituted electron-deficient alkenes. Mechanistic studies were indicative of a kinetically relevant, carboxylate-assisted C-H cobaltation.
引用
收藏
页码：2822 / 2825
页数：4
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