Synthesis and Bioactivity of (E)-2-Benzylidenimino-4-(7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran-5-yl)thiazole

被引：14

作者：

Shen, Fang ^{[1
]}

Hu, Aixi ^{[1
]}

Luo, Xianfu ^{[1
]}

Ye, Jiao ^{[1
]}

Ou, Xiaoming ^{[2
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China

[2] Hunan Res Inst Chem Ind, Changsha 410007, Hunan, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 32卷 / 02期

关键词：

(E)-2-benzylidenimino-4-(7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran-5-yl)thiazole; synthesis; insecticidal activity; fungicidal activity; herbicidal activity; BIOLOGICAL-ACTIVITY; CARBOFURAN;

D O I：

10.6023/cjoc1108151

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sixteen (E)-2-benzylidenimino-4-(7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran-5-yl)thiazoles were synthesized from 2,3-dihydro-2,2-dimethyl-7-benzofuranol by etherification, Friedel-Crafts acylation, alpha-bromation, cyclization of thiazole and imidization. Their structures were clearly established by H-1 NMR, MS spectra and elemental analysis. The preliminary bioassays indicated that compounds 2a and 21 exhibited insecticidal activity against T. urticae were 53.10% and 67.71% at 500 mg/L. Compounds 2a and 2k exhibited fungicidal activity against S. sclerotiorum were 57.9% and 59.8% at 25 mg/L. Compound 21 showed different degrees of herbicidal activity against A. theophrasti, A. spinosus L and C. album at 2250 g.ai/ha.

引用

页码：388 / 392

页数：5

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