Therapeutic role of mitoxantrone in multiple sclerosis

被引：50
|
作者：
Neuhaus, O [1 ]
Kieseier, BC [1 ]
Hartung, HP [1 ]
机构：
[1] Univ Dusseldorf, Dept Neurol, D-40225 Dusseldorf, Germany
来源：
PHARMACOLOGY & THERAPEUTICS | 2006年 / 109卷 / 1-2期
关键词：
multiple sclerosis; pathogenesis; immunotherapy; immunosuppression; immunomodulation; mitoxantrone;
D O I：
10.1016/j.pharmthera.2005.07.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Mitoxantrone is approved by several health authorities for treatment of active forms of relapsing-remitting or secondary progressive multiple sclerosis (SPMS). This review provides an outline on relevant preclinical as well as clinical studies, places mitoxantrone in the context of other therapeutic approaches against multiple sclerosis (MS), and discusses relevant side effects. The current knowledge of the putative mechanisms of action of the compound is discussed. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：198 / 209
页数：12
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