Traumatic brain injury: Can the consequences be stopped?

被引：198
|
作者：
Park, Eugene [1 ]
Bell, Joshua D. [1 ,2 ,3 ]
Baker, Andrew J. [1 ,2 ,3 ]
机构：
[1] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Cara Phelan Ctr Trauma Res, Toronto, ON M5B 1W8, Canada
[2] Univ Toronto, Inst Med Sci, Dept Anesthesia, Toronto, ON M5S 1A1, Canada
[3] Univ Toronto, Dept Surg, Toronto, ON, Canada
来源：
CANADIAN MEDICAL ASSOCIATION JOURNAL | 2008年 / 178卷 / 09期
关键词：
D O I：
10.1503/cmaj.080282
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Traumatic brain injury is a leading cause of morbidity and death in both industrialized and developing countries. To date, there is no targeted pharmacological treatment that effectively limits the progression of secondary injury. The delayed progression of deterioration of grey and white matter gives hope that a meaningful intervention can be applied in a realistic timeframe following initial trauma. In this review we discuss new insights into the subcellular mechanisms of secondary injury that have highlighted numerous potential targets for intervention.
引用
收藏
页码：1163 / 1170
页数：8
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