Assessing baloxavir susceptibility of influenza viruses circulating in the United States during the 2016/17 and 2017/18 seasons

被引：87
|
作者：
Gubareva, Larisa V. [1 ]
Mishin, Vasiliy P. [1 ]
Patel, Mira C. [1 ,2 ]
Chesnokov, Anton [1 ]
Nguyen, Ha T. [1 ,2 ]
De La Cruz, Juan [1 ,2 ]
Spencer, Sarah [1 ]
Campbell, Angela P. [1 ]
Sinner, Mallory [3 ]
Reid, Heather [3 ]
Garten, Rebecca [1 ]
Katz, Jackie M. [1 ]
Fry, Alicia M. [1 ]
Barnes, John [1 ]
Wentworth, David E. [1 ]
机构：
[1] Ctr Dis Control & Prevent CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA
[2] Battelle Mem Inst, Atlanta, GA USA
[3] Illinois Dept Publ Hlth, Springfield, IL 62761 USA
来源：
EUROSURVEILLANCE | 2019年 / 24卷 / 03期
关键词：
D O I：
10.2807/1560-7917.ES.2019.24.3.1800666
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The anti-influenza therapeutic baloxavir targets cap-dependent endonuclease activity of polymerase acidic (PA) protein. We monitored baloxavir susceptibility in the United States with next generation sequencing analysis supplemented by phenotypic one-cycle infection assay. Analysis of PA sequences of 6,891 influenza A and B viruses collected during 2016/17 and 2017/18 seasons showed amino acid substitutions: I38L (two A(H1N1) pdm09 viruses), E23G (two A(H1N1) pdm09 viruses) and I38M (one A(H3N2) virus); conferring 4-10-fold reduced susceptibility to baloxavir.
引用
收藏
页码：13 / 17
页数：5
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