Total synthesis of (±)-mersicarpine following a 6-exo-trig radical cyclization

被引：2

作者：

Peng, Wan-Ling ^{[1
]}

Jhang, Yin-Jia ^{[1
]}

Chang, Chieh-Yu ^{[1
]}

Peng, Po-Kai ^{[1
]}

Zhao, Wei-Ting ^{[1
]}

Wu, Yen-Ku ^{[1
]}

机构：

[1] Natl Yang Ming Chiao Tung Univ, Dept Appl Chem, 1001 Univ Rd, Hsinchu 30010, Taiwan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 31期

关键词：

CATALYZED ALPHA-ARYLATION; FORMAL SYNTHESIS; MERSICARPINE; LEUCONOXINE; (-)-LEUCONOXINE; LEUCONODINES; ALKALOIDS; CONCISE;

D O I：

10.1039/d2ob00620k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Described is a total synthesis of racemic mersicarpine from diethyl 4-oxopimelate. The synthetic route takes advantage of a 2-indolyl radical cyclization to construct the pyrido[1,2-a]indole scaffold bearing the all-carbon quaternary stereocenter.

引用

页码：6193 / 6195

页数：3

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