Biodegradability of mesoporous silica nanoparticles

被引：27
|
作者：
Hu, Yao [1 ]
Bai, Song [1 ]
Wu, Xiaozan [2 ]
Tan, Songwen [3 ]
He, Yongju [1 ]
机构：
[1] Cent South Univ, Sch Mat Sci & Engn, Changsha 410083, Hunan, Peoples R China
[2] Cent South Univ, Sci Pk, Changsha 410083, Hunan, Peoples R China
[3] Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Hunan, Peoples R China
来源：
CERAMICS INTERNATIONAL | 2021年 / 47卷 / 22期
基金：
中国国家自然科学基金;
关键词：
Mesoporous silica; Biodegradability; Doping; Metal ion; Organic species; UNIQUE DEGRADATION BEHAVIOR; IN-VIVO; DRUG-DELIVERY; ORGANOSILICA NANOPARTICLES; CANCER-CELLS; RELEASE; CARRIER; BIODISTRIBUTION; SHAPE; SIZE;
D O I：
10.1016/j.ceramint.2021.08.129
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Biodegradability significantly impacts the bioapplication of mesoporous silica nanoparticles (MSN). In recent years, immense efforts have been made to understand and tailor the biodegradability of MSN. In this mini review, we overview the recent reports on the biodegradation of MSN, with a focus on the correlation between biodegradation and physicochemical properties including specific surface area, morphology, pore size, particle diameter and condensation degree of silicon-oxygen network. In addition, strategies for improving the biodegradability of MSN such as metal ions and organic species doping are also introduced.
引用
收藏
页码：31031 / 31041
页数：11
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