Human Herpes Simplex Virus: Life Cycle and Development of Inhibitors

被引：119
|
作者：
Kukhanova, M. K. [1 ]
Korovina, A. N. [1 ]
Kochetkov, S. N. [1 ]
机构：
[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2014年 / 79卷 / 13期
基金：
俄罗斯基础研究基金会;
关键词：
HSV; herpes simplex; life cycle; replication; drugs; mutations; resistance; TYPE-1; DNA-POLYMERASE; HELICASE-PRIMASE INHIBITORS; NUCLEAR-LOCALIZATION SIGNAL; GUINEA-PIG MODEL; THYMIDINE KINASE; VIRAL REPLICATION; C-TERMINUS; IN-VITRO; HERPES-SIMPLEX-VIRUS-1; DNA; ANTIHERPESVIRUS ACTIVITY;
D O I：
10.1134/S0006297914130124
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes, conjunctivitis, eczema herpeticum, and other diseases. Herpesvirus almost always accompanies HIV-infection and complicates AIDS treatment. Herpes simplex virus type 1 is one of the most wide spread viruses from the Herpesviridae family. HSV virion, genome structure, replication mechanisms, antiherpes drug development strategies, including design of prodrugs, and mutations causing ACV-resistance in clinical HSV isolates are discussed in this review.
引用
收藏
页码：1635 / 1652
页数：18
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