Polyunsaturated fatty acid regulation of gene expression

被引：61

作者：

Sampath, H ^{[1
]}

Ntambi, JM

机构：

[1] Univ Wisconsin, Dept Nutr Sci, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Nutr Sci, Madison, WI 53706 USA

[3] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

[4] Univ Wisconsin, Dept Nutr Sci, Madison, WI 53706 USA

来源：

NUTRITION REVIEWS | 2004年 / 62卷 / 09期

关键词：

polyunsaturated fatty acids; SREBP1c; PPAR-alpha; HNF-4; alpha; LXR alpha;

D O I：

10.1301/nr.2004.sept.333-339

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Polyunsaturated fatty acids (PUFAs), specifically the n-3 series, have been implicated in the prevention of various human diseases, including obesity, diabetes, coronary heart disease and stroke, and inflammatory and neurologic diseases. PUFAs function mainly by altering membrane lipid composition, cellular metabolism, signal transduction, and regulation of gene expression. PUFAs regulate the expression of genes in various tissues, including the liver, heart, adipose tissue, and brain. The role of transcription factors such as SREBP1c and nuclear receptors such as PPAR-alpha, HNF-4alpha, and LXRalpha in mediating the nuclear effects of PUFAs are addressed.

引用

页码：333 / 339

页数：7

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