Zinc as a Therapeutic Agent in Bone Regeneration

被引：147
|
作者：
O'Connor, J. Patrick [1 ,2 ]
Kanjilal, Deboleena [2 ]
Teitelbaum, Marc [2 ]
Lin, Sheldon S. [1 ,2 ]
Cottrell, Jessica A. [3 ]
机构：
[1] Rutgers New Jersey Med Sch, Dept Orthopaed, Newark, NJ 07103 USA
[2] Rutgers State Univ, Sch Grad Studies, 185 South Orange Ave, Newark, NJ 07103 USA
[3] Seton Hall Univ, Dept Biol Sci, 400 South Orange Ave, S Orange, NJ 07079 USA
来源：
MATERIALS | 2020年 / 13卷 / 10期
基金：
美国国家卫生研究院;
关键词：
zinc; bone regeneration; bone healing; osteogenesis; therapeutics; bone biology; osteoclasts; osteoblasts; chondrocytes; OSTEOBLASTIC MC3T3-E1 CELLS; MOUSE MARROW CULTURE; ALKALINE-PHOSPHATASE ACTIVITY; BETA-TRICALCIUM PHOSPHATE; MESENCHYMAL STEM-CELLS; CALCIUM-PHOSPHATE; GROWTH-PLATE; IN-VITRO; ACRODERMATITIS-ENTEROPATHICA; OXIDATIVE STRESS;
D O I：
10.3390/ma13102211
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Zinc is an essential mineral that is required for normal skeletal growth and bone homeostasis. Furthermore, zinc appears to be able to promote bone regeneration. However, the cellular and molecular pathways through which zinc promotes bone growth, homeostasis, and regeneration are poorly understood. Zinc can positively affect chondrocyte and osteoblast functions, while inhibiting osteoclast activity, consistent with a beneficial role for zinc in bone homeostasis and regeneration. Based on the effects of zinc on skeletal cell populations and the role of zinc in skeletal growth, therapeutic approaches using zinc to improve bone regeneration are being developed. This review focuses on the role of zinc in bone growth, homeostasis, and regeneration while providing an overview of the existing studies that use zinc as a bone regeneration therapeutic.
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页数：22
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