Continuous Positive Airway Pressure Ventilation for Acute Ischemic Stroke A Randomized Feasibility Study

被引:61
|
作者
Minnerup, Jens [1 ]
Ritter, Martin Andreas [1 ]
Wersching, Heike [2 ]
Kemmling, Andre [3 ]
Okegwo, Angelika [1 ]
Schmidt, Antje [1 ]
Schilling, Matthias [1 ]
Ringelstein, E. Bernd [1 ]
Schaebitz, Wolf Ruediger [4 ]
Young, Peter [1 ]
Dziewas, Rainer [1 ]
机构
[1] Univ Munster, Dept Neurol, D-48149 Munster, Germany
[2] Univ Munster, Inst Epidemiol & Social Med, D-48149 Munster, Germany
[3] Univ Munster, Inst Clin Radiol, D-48149 Munster, Germany
[4] Neurol Bethel, EVK Bielefeld, Bielefeld, Germany
关键词
continuous positive airway pressure ventilation; stroke; ATTACK; TRIAL;
D O I
10.1161/STROKEAHA.111.637611
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose-Sleep-related breathing disorders occur frequently after stroke. We assessed the feasibility of continuous positive airway pressure (CPAP) treatment initiated in the first night after stroke. Methods-In this open-label, parallel-group trial, 50 patients were randomly assigned to the CPAP therapy or to the control group. All patients underwent polysomnography in the fourth night. Intervention patients received CPAP therapy for 3 nights starting the first night after stroke onset and for an additional 4 nights when polysomnography revealed an apnea-hypopnea index >10/hour. The primary end point was feasibility defined as apnea-hypopnea index reduction under CPAP treatment, nursing workload, and CPAP adherence. Results-The apnea-hypopnea index under CPAP treatment was significantly reduced (32.2 +/- 25.3-9.8 +/- 6.6, P = 0.0001). Nursing workload did not significantly differ between the CPAP (n = 25) and the control group (n = 25; P = 0.741). Ten patients (40.0%) had excellent CPAP use, 14 patients (56.0%) had some use, and 1 patient (4.0%) had no use. There was a trend toward greater National Institutes of Health Stroke Scale score improvement until Day 8 in patients on CPAP (2.00 versus 1.40, P = 0.092) and a significantly greater National Institutes of Health Stroke Scale score improvement in patients with excellent CPAP use when compared with control patients (2.30 versus 1.40, P = 0.022). Conclusions-CPAP therapy initiated in the first night after stroke seems to be feasible and was not associated with neurological deterioration.
引用
收藏
页码:1137 / U388
页数:8
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