Titanium-Mediated Domino Cross-Coupling/Cyclodehydration and Aldol-Addition/Cyclocondensation: Concise and Regioselective Synthesis of Polysubstituted and Fused Furans

被引：7

作者：

Ren, Lu ^{[1
]}

Luo, Juan ^{[1
]}

Tan, Linbo ^{[1
]}

Tang, Qiang ^{[1
]}

机构：

[1] Chongqing Med Univ, Ctr Lab Teaching & Management, Coll Pharm, Chongqing 400016, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 05期

关键词：

ALPHA; BETA-UNSATURATED CARBONYL-COMPOUNDS; ONE-POT; ENOL ETHERS; KETONES; ACID; TETRACHLORIDE; DERIVATIVES; ACCESS; CYCLOISOMERIZATION; HYDROAMINATION;

D O I：

10.1021/acs.joc.1c02894

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Titanium enolates, in situ-generated from readily available ketones and titanium tetraisopropoxide, undergo domino cross-coupling/cyclodehydration or domino Aldol-addition/cyclocondensation with alpha-chloroketones to provide synthetically valuable furan derivatives. The domino process tolerates a variety of cyclic and acyclic ketones and chloroketones, producing polysubstituted furans and bi-, tri-, and tetracyclic fused furans.

引用

页码：3167 / 3176

页数：10

共 6 条

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RSC ADVANCES, 2015, 5 (64) : 51581 - 51585
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TETRAHEDRON LETTERS, 2014, 55 (09) : 1593 - 1596
[6] Straightforward Synthesis of 2(5H)-Furanones as Promising Cross-Coupling Partners: Direct Furanone Annulation Utilizing Ti-Mediated Aldol Addition
Ban, Yuki
Ashida, Yuichiro
Nakatsuji, Hidefumi
Tanabe, Yoo
MOLBANK, 2016, (04)

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