The pro-oxidant activity of aluminum

被引：333
|
作者：
Exley, C [1 ]
机构：
[1] Univ Keele, Dept Chem, Birchall Ctr Inorgan Chem & Mat Sci, Keele ST5 5BG, Staffs, England
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2004年 / 36卷 / 03期
关键词：
aluminum; pro-oxidant; superoxide; Fenton chemistry; biological oxidation; free radical;
D O I：
10.1016/j.freeradbiomed.2003.11.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aluminum, a non-redox-active metal is, nevertheless, a pro-oxidant both in in vitro preparations and in vivo. It facilitates both superoxide- and iron-driven biological oxidation by mechanisms that remain to be resolved. More than 10 years ago Fridovich and colleagues suggested that the facilitation of superoxide-driven biological oxidation by aluminum was due to an interaction between the metal and the superoxide radical anion (Free Radic. Biol. Med. 13:7981; 1992). This thesis has been examined herein and it is concluded that much, if not all, of the pro-oxidant activity of aluminum might be explained by the formation of an aluminum superoxide semireduced radical ion. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码：380 / 387
页数：8
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