The effect of epidermal growth factor on circulating levels of IGF and IGF-binding proteins in adult Goettingen minipigs

被引:9
|
作者
VinterJensen, L
Juhl, CO
Frystyk, J
Dajani, EZ
Oksbjerg, N
Flyvbjerg, A
机构
[1] AARHUS UNIV,AARHUS KOMMUNE HOSP,INST EXPT CLIN RES,SURG & MED RES LABS,DK-8000 AARHUS,DENMARK
[2] INT DRUG DEV CONSULTANTS,LONG GROVE,IL
关键词
D O I
10.1677/joe.0.1510401
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
It has recently been demonstrated that epidermal growth factor (EGF) administration to neonatal rodents causes growth retardation with concomitant reductions in circulation levels of IGF-I. We describe the effects of systemic EGF administration for 4 weeks on circulating levels of IGF-I and IGF-binding proteins (IGFBPs) and on thyroid hormones (tri-iodothyronine, T-3; thyroxine, T-4) in sexually mature pig. Goettingen minipigs of either sex were treated with placebo (n=5) or EGF (30 mu g/kg per day, n=6) s.c. for 4 weeks (in relation to an oesophageal sclerotherapy regimen). Blood samples were taken under anaesthesia before and after 1, 2, 3 and 4 weeks of treatment. Circulating levels of IGF-I, insulin, glucose, T-3 and T-4 were analysed every week and IGFBPs every second week. IGF-I was not reduced significantly after 1 week but significantly reduced after 2 and 3 weeks of EGF treatment. A similar decline was observed for the major IGFBP, IGFBP-3, which was reduced after 2 and 4 weeks. IGFBP-1, IGFBP-2 and IGFBP-4 increased throughout the treatment period (all significantly at week 4). EGF treatment induced increased circulating T-3 after 2, 3 and 4 weeks of EGF treatment. In conclusion, we report that EGF treatment for 4 weeks in Goettingen minipigs reduces circulating IGF-I and IGFBP-3, increases circulating IGFBP-1, IGFBP-2 and IGFBP-4, and induces a slight hyperthyroidism as judged from increased circulating levels of T-3.
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页码:401 / 407
页数:7
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