Targeting the hedgehog signaling pathway for cardiac repair and regeneration

被引：3
|
作者：
Wang, Y. [1 ]
Lu, P. [1 ]
Zhao, D. [2 ]
Sheng, J. [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Geriatr, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China
来源：
HERZ | 2017年 / 42卷 / 07期
关键词：
Regeneration; Myocardial infarction; Cardiomyocytes; Agonists; Mesenchymal stem cells; SONIC-HEDGEHOG; OUTFLOW TRACT; HEART; STEM; CELLS; DIFFERENTIATION; REQUIREMENTS; PROGENITORS; INHIBITORS; DISCOVERY;
D O I：
10.1007/s00059-016-4500-y
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The hedgehog (Hh) signaling pathway is involved in the angiogenesis and development of the coronary vasculature in the embryonic heart. Recently, the Hh signal pathway has emerged as an important regulator that can increase cardiomyocyte proliferation, inhibit cardiomyocyte death and apoptosis, recruit endothelial progenitor cell (EPCs) into sites of myocardial ischemia, and direct stem cells to differentiate into cardiac muscle lineage. Experimental studies have tried to target the Hh signaling pathway for cardiac repair and regeneration. The purpose of this review is to discuss the role of the Hh signal pathway in cardiac repair and regeneration as well as the current strategies targeting the Hh signaling pathway and its potential in heart diseases.
引用
收藏
页码：662 / 668
页数：7
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