The role of estrogens and estrogen receptors in normal prostate growth and disease

被引：228

作者：

Prins, Gail S. ^{[1
]}

Korach, Kenneth S. ^{[2
]}

机构：

[1] Univ Illinois, Dept Urol, Chicago, IL 60612 USA

[2] NIEHS, NIH, Reprod & Dev Toxicol Lab, Environm Dis & Med Program, Res Triangle Pk, NC 27709 USA

来源：

STEROIDS | 2008年 / 73卷 / 03期

关键词：

prostate; prostate cancer; estrogens; estradiol estrogen receptor;

D O I：

10.1016/j.steroids.2007.10.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Estrogens have significant direct and indirect effects on prostate gland development and homeostasis and have been long suspected in playing a role in the etiology of prostatic diseases. Direct effects are mediated through prostatic estrogen receptors alpha (ER alpha) and beta (ER beta) with expression levels changing over time and with disease progression. The present review examines the evidence for a role of estrogens and specific estrogen receptors in prostate growth, differentiation and disease states including prostatitis, benign prostatic hyperplasia (BPH) and cancer and discusses potential therapeutic strategies for growth regulation via these pathways. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：233 / 244

页数：12

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