How does maternal age affect genomic stability in the offspring?

被引:5
|
作者
Sturm, Adam [1 ,2 ]
Vellai, Tibor [1 ,2 ]
机构
[1] Eotvos Lorand Univ, Dept Genet, Pazmany Peter Stny 1-C, H-1117 Budapest, Hungary
[2] ELKH ELTE Genet Res Grp, Budapest, Hungary
关键词
5-methylcytosine; aging; epigenetic reprogramming; genomic instability; maternal age; transposon; METHYLATION;
D O I
10.1111/acel.13612
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In high-income countries, women tend to give birth at increasingly advanced ages. Despite its physiological, developmental, and medical consequences, why this tendency significantly affects genetic stability of the offspring remains largely unresolved. Accumulating evidence indicates that the higher the age of the mother at fertilization, the more intense the activity of transposable elements causing insertional mutations in functional DNA stretches in her oocyte involved in zygote formation.
引用
收藏
页数:3
相关论文
共 50 条
  • [1] DOES MATERNAL ALCOHOLISM AFFECT OFFSPRING
    JOHNSON, CF
    [J]. CLINICAL PEDIATRICS, 1974, 13 (08) : 633 - 634
  • [2] Does Maternal Diet Affect Phenotypic Outcomes in Offspring?
    Warzak, Denise A.
    Mao, Jiude
    Keegan, Jessica A.
    Sieli, Paizlee T.
    Rosenfeld, Cheryl S.
    Roberts, R. Michael
    [J]. BIOLOGY OF REPRODUCTION, 2010, : 176 - 177
  • [3] Does Maternal Obesity Affect Offspring Intelligence Quotient (IQ)?
    Brubaker, Sara G.
    Zork, Noelia
    Pessel, Caroline
    Gyamfi-Bannerman, Cynthia
    Ananth, Cande V.
    [J]. REPRODUCTIVE SCIENCES, 2014, 21 (03) : 150A - 150A
  • [4] Does maternal age affect pregnancy outcome?
    Cohen, W. R.
    [J]. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2014, 121 (03) : 252 - 254
  • [5] Maternal Blood Pressure During Pregnancy What Is Normal and How Does it Affect Offspring Blood Pressure?
    Boyd, Heather A.
    [J]. HYPERTENSION, 2020, 76 (03) : 670 - 671
  • [6] How Does Court Stability Affect Legal Stability?
    Bustos, Alvaro
    Garoupa, Nuno
    [J]. JOURNAL OF LAW ECONOMICS & ORGANIZATION, 2024, 40 (01): : 182 - 223
  • [7] How Does Reprogramming to Pluripotency Affect Genomic Imprinting?
    Perrera, Valentina
    Martello, Graziano
    [J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019, 7
  • [8] Does maternal exposure to an environmental stressor affect offspring response to predators?
    Todd, Brian D.
    Bergeron, Christine M.
    Hepner, Mark J.
    Burke, John N.
    Hopkins, William A.
    [J]. OECOLOGIA, 2011, 166 (01) : 283 - 290
  • [9] Does maternal exposure to an environmental stressor affect offspring response to predators?
    Brian D. Todd
    Christine M. Bergeron
    Mark J. Hepner
    John N. Burke
    William A. Hopkins
    [J]. Oecologia, 2011, 166
  • [10] How does maternal stress affect offspring oxidative signaling and telomeres in wild North American red squirrels?
    Dantzer, B.
    Westrick, S. E.
    Monaghan, P.
    Boutin, S.
    Humphries, M. M.
    Lane, J. E.
    Mcadam, A. G.
    Van Kesteren, F.
    [J]. INTEGRATIVE AND COMPARATIVE BIOLOGY, 2018, 58 : E47 - E47