Forget the Parents: Epigenetic Reprogramming in Human Germ Cells

被引：61
|
作者：
von Meyenn, Ferdinand [1 ]
Reik, Wolf [1 ,2 ,3 ]
机构：
[1] Babraham Inst, Epigenet Programme, Cambridge CB22 3AT, England
[2] Univ Cambridge, Ctr Trophoblast Res, Cambridge CB2 3EG, England
[3] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
来源：
CELL | 2015年 / 161卷 / 06期
基金：
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词：
DYNAMICS; MICE;
D O I：
10.1016/j.cell.2015.05.039
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Epigenetic reprogramming in the germline resets genomic potential and erases epigenetic memory. Three studies by Gkountela et al., Guo et al., and Tang et al. analyze the transcriptional and epigenetic landscape of human primordial germ cells, revealing a unique transcriptional network and progressive and conserved global erasure of DNA methylation.
引用
收藏
页码：1248 / 1251
页数：5
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