Is there a murine model that fully recapitulates human NASH? An unbiased bioinformatics approach to rank pre-clinical models based on proximity to human disease

被引：0

作者：

Vacca, Michele ^{[1
,2
]}

Kamzolas, Ioannis ^{[1
,3
]}

Harder, Lea Morch ^{[4
]}

Oakley, Fiona ^{[5
]}

Trautwein, Christian ^{[6
]}

Hatting, Maximilian ^{[6
]}

Ross, Trenton ^{[7
]}

Bernardo, Barbara ^{[8
]}

Oldenburger, Anouk ^{[9
]}

Hjuler, Sara Toftegaard ^{[4
]}

Ksiazek, Iwona ^{[10
]}

Linden, Daniel ^{[11
,12
]}

Schuppan, Detlef ^{[13
]}

Rodriguez-Cuenca, Sergio ^{[1
]}

Tonini, Maria Manuela ^{[14
]}

Kannt, Aimo ^{[15
,16
]}

Rodriguez-Castaneda, Tamara ^{[15
]}

Rodrigues, Cecilia M. P. ^{[17
]}

Cockell, Simon ^{[18
]}

Govaere, Olivier ^{[19
]}

Daly, Ann K. ^{[19
]}

Allison, Michael ^{[20
]}

De Lichtenberg, Kristian Honnens ^{[4
]}

Kim, Yong Ook ^{[13
]}

Lindblom, Anna ^{[11
]}

Oldham, Stephanie ^{[21
]}

Andreasson, Anne-Christine ^{[11
]}

Schlerman, Franklin ^{[22
]}

Marioneaux, Jonathon ^{[23
]}

Sanyal, Arun ^{[24
]}

Afonso, Marta B. ^{[17
]}

Rinaldi, Anthony ^{[7
]}

Amano, Yuichiro ^{[25
]}

Paradis, Valerie ^{[26
]}

Burt, Alastair ^{[19
]}

Susan, Davies ^{[27
,30
]}

Driessen, Ann ^{[28
]}

Yashiro, Hiroaki ^{[29
]}

Brosnan, M. Julia

Yunis, Carla

Bedossa, Pierre ^{[31
]}

Tiniakos, Dina ^{[32
,33
]}

Anstee, Quentin ^{[32
,34
]}

Petsalaki, Evangelia ^{[3
]}

Davidsen, Peter ^{[4
]}

Perfield, Jim ^{[35
]}

Vidal-Puig, Antonio ^{[1
]}

机构：

[1] Univ Cambridge, WT MRC Inst Metab Sci, Cambridge, England

[2] Univ Bari Aldo Moro, Interdisciplinary Dept Med, Bari, Italy

[3] European Mol Biol Lab European Bioinformat Inst E, Wellcome Genome Campus, Cambridge, England

[4] Novo Nordisk Res & Early Dev, Novo Nordisk AS, Copenhagen, Denmark

[5] Newcastle Univ, Fac Med Sci, Biosci Inst, Newcastle Fibrosis Res Grp, Newcastle Upon Tyne, Tyne & Wear, England

[6] Aachen Univ Hosp, Dept Med 3, Aachen, Germany

[7] PfizerWorldwide Res & Dev, Internal Med Res Unit, Pfizer IMRU, Cambridge, MA USA

[8] PfizerWorldwide Res & Dev, Pfizer Internal Med, 558 Eastern Point Rd, Groton, CT 06340 USA

[9] Boehringer Ingelheim Pharma GmbH & Co KG, CardioMetabol Dis Res, Biberach ad Riss, Biberach, Germany

[10] Novartis Pharma AG, Novartis Inst BioMed Res, CH-4056 Basel, Switzerland

[11] AstraZeneca, BioPharmaceut RandD, Cardiovasc Renal & Metab CVRM, AstraZeneca Biosci Metab Res & Early Dev, Gothenburg, Sweden

[12] Univ Gothenburg, Sahlgrenska Acad, Dept Neuroscience & Physiol, Div Endocrinol, Gothenburg, Sweden

[13] Johannes Gutenberg Univ Med Ctr, Inst Translat Immunol & Res Ctr Immunother, Mainz, Germany

[14] Luxembourg Inst Hlth Translat Med Operat Hub, Integrated Biobank Luxembourg IBBL, Luxembourg, Luxembourg

[15] Ind Hoechst, SanofiAventis Deutschland GmbH, RandD Diabet, D-65926 Frankfurt, Germany

[16] Fraunhofer Inst Translat Med & Pharmacol ITMP, Theodor Stern Kai 7, D-60956 Frankfurt, Germany

[17] Univ Lisbon, Fac Pharm, Univ Lisbon Res Inst Med, Lisbon, Portugal

[18] Newcastle Univ, Fac Med Sci, Bioinformat Support Unit, Newcastle Upon Tyne, Tyne & Wear, England

[19] Newcastle Univ, Fac Med Sci, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England

[20] Cambridge Univ Hosp NHS Fdn Trust, Liver Unit, Cambridge NIHR Biomed Res Ctr, Cambridge, England

[21] AstraZeneca, Biosci Metab, Res & Early Dev Cardiovasc, Renal & Metab CVRM, Gaithersburg, MD USA

[22] Pfizer Worldwide Res & Dev, Pfizer Inflammat & Immunol Res Unit, Cambridge, MA USA

[23] Sanyal Biotechnol LLC, Norfolk, VA USA

[24] Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23284 USA

[25] Takeda Pharmaceut Co Ltd, Takeda Pharmaceut Int AG, Fujisawa, Kanagawa, Japan

[26] Univ Paris Diderot, Dept Imaging & Pathol, Hop Beaujon, Paris, France

[27] Cambridge Univ Hosp NHS Fdn Trust, Dept Cellular Pathol, Cambridge, England

[28] Univ Antwerp, Dept Pathol, Antwerp, Belgium

[29] Takeda Pharmaceut Co Ltd, Takeda Pharmaceut Int AG, Cambridge, MA USA

[30] Newcastle Univ, LiverPat, Paris, France

[31] Newcastle Univ, Translat & Clin Res Inst, Newcastle, NSW, France

[32] Newcastle Univ, Fac Med Sci, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England

[33] Natl & Kapodistrian Univ Athens, Aretaie Hosp, Sch Med, Athens, Greece

[34] Newcastle Univ, Newcastle Tyne Hosp NHS Trust, Newcastle NIHR Biomed Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England

[35] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA

来源：

JOURNAL OF HEPATOLOGY | 2022年 / 77卷

基金：

欧盟地平线“2020”;

关键词：

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

GS009

引用

页码：S7 / S8

页数：2

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