An eco-friendly synthesis of 2-pyrazoline derivatives catalysed by

被引:0
|
作者
Bhat, Prabhat [1 ]
Shridhar, Gomathi [2 ]
Ladage, Savita [3 ]
Ravishankar, Lakshmy [4 ]
机构
[1] Homi Bhabha Ctr Sci Educ, Bombay 400088, Maharashtra, India
[2] VK Krishna Menon Coll Commerce & SS Dighe Coll Sc, Dept Chem, Bombay 400042, Maharashtra, India
[3] Homi Bhabha Ctr Sci Educ TIFR, Bombay 400088, Maharashtra, India
[4] KETs VG Vaze Coll Arts Sci & Commerce, Dept Chem, Mithagar Rd, Bombay 400081, Maharashtra, India
关键词
Cerium chloride heptahydrate; ethyl lactate; green solvent; chalcones; 1; 3; 5-Triaryl-2-pyrazoline; ETHYL LACTATE; ACID; SOLVENT; 1,3,5-TRIARYL-2-PYRAZOLINES; PYRAZOLINES; ALDEHYDES;
D O I
10.1007/s12039-017-1327-x
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
1,3,5-triaryl-2-pyrazoline derivatives were synthesised by a condensation reaction between chalcones and phenyl hydrazine using cerium chloride heptahydrate as a catalyst. All these reactions were carried out in ethyl lactate (70%) as a green solvent. Easy and efficient work up, recyclability of solvent and catalyst are the key merits of this protocol. SYNOPSIS A facile protocol for the synthesis of 1,3,5-triaryl-2-pyrazolines is described. The solvent ethyl lactate, obtained from renewable sources, is biodegradable. The catalyst is a water-tolerant Lewis acid with low toxicity. Easy and clean work up, recyclable solvent and catalyst are merits of the protocol. The reaction works well for all systems giving good yields of the desired products.
引用
收藏
页码:1441 / 1448
页数:8
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