Vaccination with a modified vaccinia virus Ankara (MVA)-vectored HIV-1 immunogen induces modest vector-specific T cell responses in human subjects

被引：17

作者：

Howles, Sarah ^{[1
]}

Guimaraes-Walker, Ana ^{[1
]}

Yang, Hongbing ^{[1
]}

Hancock, Gemma ^{[1
,2
]}

di Gleria, Katalin ^{[1
]}

Tarragona-Fiol, Tony ^{[3
]}

Hayes, Peter ^{[3
]}

Gilmour, Jill ^{[3
]}

Bridgeman, Anne ^{[1
]}

Hanke, Tomas ^{[1
]}

McMichael, Andrew ^{[1
,2
]}

Dorrell, Lucy ^{[1
,2
]}

机构：

[1] John Radcliffe Hosp, MRC Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England

[2] John Radcliffe Hosp, Oxford NIHR Biomed Res Ctr, Weatherall Inst Mol Med, Oxford OX3 9DS, England

[3] Univ London Imperial Coll Sci Technol & Med, IAVI Core Lab, Chelsea & Westminster Hosp, London SW10 9NH, England

来源：

VACCINE | 2010年 / 28卷 / 45期

基金：

英国医学研究理事会;

关键词：

HIV-1; vaccine; Modified vaccinia virus Ankara (MVA); T cell; Human; Clinical trial; THERAPEUTIC VACCINATION; ANTIRETROVIRAL THERAPY; TYPE-1; CLADE; EPITOPES; GAG; DNA; SMALLPOX; SAFETY; MVA; IMMUNODOMINANCE;

D O I：

10.1016/j.vaccine.2010.08.077

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated whether vaccination of healthy HIV-seronegative and HIV-1-seropositive antiretroviral therapy-treated subjects with recombinant modified vaccinia virus Ankara expressing an HIV-1 immunogen (MVA.HIVA) induced MVA-specific T cell responses. Using IFN-gamma Elispot assays, we observed new or increased responses to MVA virus in 52% of HIV-seronegative subjects and 93% HIV-1 seropositive subjects; MVA-specific T cell frequencies were generally low and correlated poorly with T cell responses to the HIV-1 immunogen. In two vaccinees, responses were mapped to CD8+ T cell epitopes present in replication-competent vaccinia virus. These data support further evaluation of MVA as a viral vector for HIV-1 immunogens. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：7306 / 7312

页数：7

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