Posttranslational Modifications of RAS Proteins

被引：52
|
作者：
Ahearn, Ian [1 ]
Zhou, Mo [1 ]
Philips, Mark R. [1 ]
机构：
[1] NYU, Sch Med, Perlmutter Canc Ctr, Dept Med, New York, NY 10016 USA
来源：
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2018年 / 8卷 / 11期
关键词：
SMALL-MOLECULE INHIBITION; ONCOGENIC K-RAS; GUANINE-NUCLEOTIDE EXCHANGE; P21(RAS) S-NITROSYLATION; NITRIC-OXIDE SYNTHASE; H-RAS; PLASMA-MEMBRANE; ISOPRENYLCYSTEINE CARBOXYLMETHYLTRANSFERASE; N-RAS; FATTY-ACYLATION;
D O I：
10.1101/cshperspect.a031484
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The three human RAS genes encode four proteins that play central roles in oncogenesis by acting as binary molecular switches that regulate signaling pathways for growth and differentiation. Each is subject to a set of posttranslational modifications (PTMs) that modify their activity or are required for membrane targeting. The enzymes that catalyze the various PTMs are potential targets for anti-RAS drug discovery. The PTMs of RAS proteins are the focus of this review.
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页数：17
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