The HIV-1 envelope glycoproteins: Fusogens, antigens, and immunogens

被引：1281
|
作者：
Wyatt, R
Sodroski, J [1 ]
机构：
[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol AIDS,Dept Pathol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
来源：
SCIENCE | 1998年 / 280卷 / 5371期
关键词：
D O I：
10.1126/science.280.5371.1884
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The human immunodeficiency virus-type 1 (HIV-1) envelope glycoproteins interact with receptors on the target cell and mediate virus entry by fusing the viral and cell membranes. The structure of the envelope glycoproteins has evolved to fulfill these functions while evading the neutralizing antibody response. An understanding of the viral strategies for immune evasion should guide attempts to improve the immunogenicity of the HIV-1envelope glycoproteins and, ultimately, aid in HIV-1vaccine development.
引用
收藏
页码：1884 / 1888
页数：5
相关论文
共 50 条
  • [1] HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens
    [J]. Science, 5371 (1884-1888):
  • [2] Evaluations of Subtype C HIV-1 Envelope Glycoproteins as Immunogens for Vaccine Development
    Dey, A. K.
    Zambonelli, C.
    Nandi, A.
    Stephenson, S.
    Sirokman, K.
    Hilt, S.
    Martinez-Guzman, D.
    Cisto, J.
    Ramesh, P.
    Wininger, M.
    Sun, Y.
    Legg, H.
    Hartog, K.
    Lai, R. Pei-Jen
    Heeney, J.
    Montefiori, D.
    Carfi, A.
    Barnett, S. W.
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 2011, 27 (10) : A134 - A134
  • [3] Centralized HIV-1 envelope immunogens and neutralizing antibodies
    Gao, Feng
    Liao, Hua-Xin
    Hahn, Beatrice H.
    Letvin, Norman L.
    Korber, Bette T.
    Haynes, Barton F.
    [J]. CURRENT HIV RESEARCH, 2007, 5 (06) : 572 - 577
  • [4] Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens
    Sattentau, Quentin J.
    [J]. VACCINES, 2013, 1 (04):
  • [5] The Conformational States of the HIV-1 Envelope Glycoproteins
    Wang, Qian
    Finzi, Andres
    Sodroski, Joseph
    [J]. TRENDS IN MICROBIOLOGY, 2020, 28 (08) : 655 - 667
  • [6] Structure of trimeric HIV-1 envelope glycoproteins
    Subramaniam, Sriram
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (45) : E4172 - E4174
  • [7] Biodiversity and bioseparation of HIV-1 envelope glycoproteins
    Shao, YM
    Lu, YC
    [J]. CRITICAL REVIEWS IN ONCOGENESIS, 1999, 10 (1-2): : 1 - 16
  • [8] Ancestral and consensus envelope immunogens for HIV-1 subtype C
    Kothe, Denise L.
    Li, Yingying
    Decker, Julie M.
    Bibollet-Ruche, Frederic
    Zammit, Kenneth P.
    Salazar, Maria G.
    Chen, Yalu
    Weng, Zhiping
    Weaver, Eric A.
    Gao, Feng
    Haynes, Barton F.
    Shaw, George M.
    Korber, Bette T. M.
    Hahn, Beatrice H.
    [J]. VIROLOGY, 2006, 352 (02) : 438 - 449
  • [9] Env Exceptionalism: Why Are HIV-1 Env Glycoproteins Atypical Immunogens?
    Klasse, P. J.
    Ozorowski, Gabriel
    Sanders, Rogier W.
    Moore, John P.
    [J]. CELL HOST & MICROBE, 2020, 27 (04) : 507 - 518
  • [10] Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures
    Harris, Audray
    Borgnia, Mario J.
    Shi, Dan
    Bartesaghi, Alberto
    He, Haifeng
    Pejchal, Robert
    Kang, Yun
    Depetris, Rafael
    Marozsan, Andre J.
    Sanders, Rogier W.
    Klasse, Per Johan
    Milne, Jacqueline L. S.
    Wilson, Ian A.
    Olson, William C.
    Moore, John P.
    Subramaniam, Sriram
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (28) : 11440 - 11445
12345