Separation of Isomers L-Alanine and Sarcosine in Urine by Electrospray Ionization and Tandem Differential Mobility Analysis-Mass Spectrometry

被引：31

作者：

Martinez-Lozano, Pablo ^{[1
]}

Rus, Juan ^{[2
]}

机构：

[1] CNR, Inst Biomed Technol, I-20090 Milan, Italy

[2] SEADM, Valladolid, Spain

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2010年 / 21卷 / 07期

关键词：

AMINO-ACIDS;

D O I：

10.1016/j.jasms.2010.02.021

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Sarcosine, an isomer of L-alanine, has been proposed as a prostate cancer progression biomarker [1]. Both compounds are detected in urine, where the measured sarcosine/alanine ratio has been found to be higher in prostate biopsy-positive group versus controls. We present here preliminary evidence showing that urine samples spiked with sarcosine/alanine can be partially resolved in 3 min via tandem differential mobility analysis-mass spectrometry (DMA-MS). Based on the calibration curves obtained for two mobility peaks, we finally estimate their concentration ratio in urine. (J Am Soc Mass Spectrom 2010, 21, 1129-1132) (C) 2010 American Society for Mass Spectrometry

引用

页码：1129 / 1132

页数：4

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