Synthesis and opener properties of novel derivatives of N-phenylanthranilic acid on recombinant KCNQ2/Q3 potassium channels: biological activity in cortical neurons

被引:0
|
作者
Peretz, A
Sheinin, A
Shamgar, L
Gopin, A
Shamis, M
Nachman, R
Shabat, D
Attali, B
机构
[1] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel
[2] Tel Aviv Univ, Sch Chem, IL-69978 Tel Aviv, Israel
关键词
D O I
暂无
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
引用
收藏
页码:451A / 451A
页数:1
相关论文
共 29 条
  • [1] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF N-PHENYLANTHRANILIC ACID-DERIVATIVES
    GAIDUKEVICH, AN
    LEVITIN, EY
    KRAVCHENKO, AA
    KAZAKOV, GP
    MIKITENKO, EE
    ARSENIEVA, TI
    PINCHUK, VV
    BELETSKAYA, OV
    ZAKHAROVA, TI
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1985, 19 (03): : 165 - 168
  • [2] Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties
    Peretz, A
    Degani, N
    Nachman, R
    Uziyel, Y
    Gibor, G
    Shabat, D
    Attali, B
    MOLECULAR PHARMACOLOGY, 2005, 67 (04) : 1053 - 1066
  • [3] Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels
    Wickenden, AD
    Yu, WF
    Zou, A
    Jegla, T
    Wagoner, PK
    MOLECULAR PHARMACOLOGY, 2000, 58 (03) : 591 - 600
  • [4] KCNQ2/3 Voltage Gated Potassium Channels Regulate the Activity of Intrapancreatic Neurons
    Levi, Noah
    Tamayo, Alejandro M.
    Makhmutova, Madina
    Caicedo, Alejandro
    DIABETES, 2024, 73
  • [5] Novel Amino-Nicotinamide Derivatives as Modulators of KCNQ2/3 Potassium Channels
    Rosse, Gerard
    ACS MEDICINAL CHEMISTRY LETTERS, 2013, 4 (01): : 10 - 11
  • [6] N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy
    Amato, George
    Roeloffs, Rosemarie
    Rigdon, Greg C.
    Antonio, Brett
    Mersch, Theresa
    McNaughton-Smith, Grant
    Wickenden, Alan D.
    Fritch, Paul
    Suto, Mark J.
    ACS MEDICINAL CHEMISTRY LETTERS, 2011, 2 (06): : 481 - 484
  • [7] (S,E)-N-[1-(3-Heteroarylphenyl)ethyl]-3-(2-fluorophenyl)- acrylamides:: synthesis and KCNQ2 potassium channel opener activity
    L'Heureux, A
    Martel, A
    He, H
    Chen, J
    Sun, LQ
    Starrett, JE
    Natale, J
    Dworetzky, SI
    Knox, RJ
    Harden, DG
    Weaver, D
    Thompson, MW
    Wu, YJ
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (02) : 363 - 366
  • [8] N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243):: A novel, selective KCNQ2/Q3 potassium channel activator
    Wickenden, A. D.
    Krajewski, J. L.
    London, B.
    Wagoner, P. K.
    Wilson, W. A.
    Clark, S.
    Roeloffs, R.
    McNaughton-Smith, G.
    Rigdon, G. C.
    MOLECULAR PHARMACOLOGY, 2008, 73 (03) : 977 - 986
  • [10] Discovery, Synthesis, and Structure-Activity Relationship of a Series of N-Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener
    Yu, Haibo
    Wu, Meng
    Townsend, Steven D.
    Zou, Beiyan
    Long, Shunyou
    Daniels, J. Scott
    McManus, Owen B.
    Li, Min
    Lindsley, Craig W.
    Hopkins, Corey R.
    ACS CHEMICAL NEUROSCIENCE, 2011, 2 (10): : 572 - 577