Distribution of ytterbium-169 in rat brain after intravenous injection

被引：33
|
作者：
Xiao, HQ [1 ]
Li, FL [1 ]
Zhang, ZY [1 ]
Feng, LX [1 ]
Li, ZJ [1 ]
Yang, JH [1 ]
Chai, ZF [1 ]
机构：
[1] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100039, Peoples R China
来源：
TOXICOLOGY LETTERS | 2005年 / 155卷 / 02期
基金：
中国国家自然科学基金;
关键词：
ytterbium; brain; lanthanides; distribution; radioactive tracer technique;
D O I：
10.1016/j.toxlet.2004.09.021
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
It is well known that lanthanides have come into extensive and rapid use in a number of fields. As a result, more and more lanthanides are getting into the environment and food chains. However, the distributions of lanthanides in brain are not yet very clear. In this study, adult Sprague-Dawley male rats were intravenously injected with 0.5 ml of (YbCl3)-Yb-169 solution (containing 10 mug Yb). The brains were perfused with saline to minimize the blood influence. The radioactivities of Yb-169 in the five brain regions (hypothalamus, cerebellum, hippocampus, corpus striatum and cerebral cortex) were counted. The results suggested that Yb did enter into the brain. Though only about 0.005% of the given dose was accumulated in the brain, Yb seemed to remain in the brain for long time. The highest specific activities were observed in the hypothalamus, hippocampus and cerebellum. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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页码：247 / 252
页数：6
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