Simulations of dynamics of actin filaments by remodeling them in shear flows

被引：7
|
作者：
Inoue, Yasuhiro [1 ,3 ]
Deji, Takeji [3 ]
Shimada, Yoshitaka [3 ]
Hojo, Masaki
Adachi, Taiji [2 ,3 ]
机构：
[1] Kyoto Univ, Dept Mech Engn & Sci, Sakyo Ku, Kyoto, Japan
[2] Kyoto Univ, Inst Frontier Med Sci, Kyoto, Japan
[3] RIKEN, Computat Cell Biomech Team, Saitama, Japan
来源：
COMPUTERS IN BIOLOGY AND MEDICINE | 2010年 / 40卷 / 11-12期
关键词：
Actin remodeling; Non-Newtonian fluid; Multiparticle collision dynamics; Mesoscopic biomolecular model; FIBER ORIENTATION; IN-VITRO; F-ACTIN; BEHAVIOR; MODULUS; MODEL;
D O I：
10.1016/j.compbiomed.2010.09.008
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A mechanochemical relationship between intracellular flow fields of actin and remodeling of actin filaments is important to the realization of cell motility. In this study, to investigate this mechanochemical relationship, we present a mathematical model describing motions of actin filament and remodeling of the filaments in shear flows. We perform simulations of the dynamics of actin filaments remodeled by polymerization, depolymerization, and severing, and investigate contributions of these remodeling processes to effective shear viscosities of the system. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：876 / 882
页数：7
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