Menstrual cycle resumption and female fertility after autologous hematopoietic stem cell transplantation for multiple sclerosis

被引：10

作者：

Massarotti, Claudia ^{[1
,2
]}

Sbragia, Elvira ^{[1
]}

Boffa, Giacomo ^{[1
]}

Vercelli, Caterina ^{[3
]}

Zimatore, Giovanni Bosco ^{[4
]}

Cottone, Salvatore ^{[5
]}

Frau, Jessica ^{[6
]}

Raiola, Annamaria ^{[7
]}

Varaldo, Riccardo ^{[7
]}

Mancardi, Gianluigi ^{[1
,8
]}

Inglese, Matilde ^{[1
,9
]}

Anserini, Paola ^{[9
]}

机构：

[1] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet & Maternal, Genoa, Italy

[2] IRCCS Osped Policlin San Martino, Acad Unit Obstet & Gynecol, Genoa, Italy

[3] Univ Genoa, Sch Med, Genoa, Italy

[4] Osped Gen Reg F Miulli Acquavia Fonti, Dept Neurol, Puglia, Italy

[5] Villa Sofia Cervello United Hosp, Palermo, Italy

[6] ATS Sardegna, ASSL Cagliari, Binaghi Hosp, Multiple Sclerosis Ctr, Cagliari, Italy

[7] IRCCS Osped Policlin San Martino, Div Hematol & Bone Marrow Transplantat, Genoa, Italy

[8] Sci Clin Inst Maugeri IRCCS, Pavia, Italy

[9] IRCCS Osped Policlin San Martino, Physiopathol Human Reprod Unit, Genoa, Italy

来源：

MULTIPLE SCLEROSIS JOURNAL | 2021年 / 27卷 / 13期

关键词：

Aggressive multiple sclerosis; amenorrhea; autologous hematopoietic stem cell transplantation; fertility; menstrual cycle; WOMEN; PREGNANCY;

D O I：

10.1177/13524585211000616

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Data on fertility after autologous hematopoietic stem cell transplantation (aHSCT) in women with multiple sclerosis (MS) are inconclusive. This study aims to report on post-aHSCT menstrual resumption in a multi-center MS-women cohort. Out of 43 women, 30 (70%) recovered menses after a mean time of 6.8 months. Older age (odds ratio (OR) = 0.5, p < 0.0001) and previous pulsed cyclophosphamide (OR = 0.44, p = 0.005) were independently associated with a reduced menstrual recovery probability. Conditioning regimens' intensity resulted not associated with post-procedure amenorrhea. Our results highlight younger age as significantly associated with menses recovery; proper fertility counseling for MS women candidated to aHSCT both prior- and post-transplantation is therefore warranted.

引用

页码：2103 / 2107

页数：5

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