Construction of Rhodamine and Gene Co-delivery Nanoparticles

被引：0
|
作者：
Wang You-Xiang [1 ]
Shen Xiao-Bo [1 ]
Xu Zhi-Xue [1 ]
Hu Qiao-Ling [1 ]
机构：
[1] Zhejiang Univ, Dept Polymer Sci & Engn, Minist Educ, Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Peoples R China
来源：
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2011年 / 32卷 / 05期
关键词：
Non-viral gene vector; Supramolecular assembly; Drug and gene co-delivery; DRUG-DELIVERY; MICELLES; POLYPLEXES; COPOLYMER; RELEASE; SYSTEMS; DNA;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The hydrophobic fluorescent dye rhodamine B was chosen as a model drug. PEI-g-cholesterol amphiphilic polymer was synthesized as drug carrier. By selecting proper conditions, rhodamine B and gene co-delivery nanoparticles were successfully constructed via supramolecular assembly. The co-delivery particles with diameter about 154 nm and xi-potential about 33. 7 mV could effectively condense DNA. The in vitro cell culture experiments indicated that the positive co-delivery nanoparticles were easily uptaked by HEK293 cells and showed effective transfection efficiency.
引用
收藏
页码：1221 / 1224
页数：4
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