Synthesis of Unsymmetrical Arylheteroarylmethanes by Direct "On Water" Cross-Coupling between Benzylic and Heteroaromatic Halides

被引：22
|
作者：
Krasovskaya, Valeria [1 ]
Krasovskiy, Arkady [1 ]
Lipshutz, Bruce H. [1 ]
机构：
[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
来源：
CHEMISTRY-AN ASIAN JOURNAL | 2011年 / 6卷 / 08期
关键词：
arylheteroarylmethanes; benzyl halides; cross-coupling; organozinc reagents; water; DIHYDROFOLATE-REDUCTASE; PNEUMOCYSTIS-CARINII; DIARYLMETHANES; INHIBITORS; PHOSPHATES; SULFONATES; CATALYSIS; REAGENTS; BROMIDES; ANALOGS;
D O I：
10.1002/asia.201100153
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Walking on water: Pharmacologically important unsymmetrical arylheteroarylmethanes are prepared by simple palladium-catalyzed zinc-mediated Negishi-like cross-couplings in good yields. This reaction tolerates various benzylic chlorides and heteroaromatic bromides "on water" and at room temperature. © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1974 / 1976
页数：3
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