Preparation and properties of biodegradable microspheres containing 5-fluorouracil

被引：0

作者：

Yin, JB

Chen, HD

Luo, K

Zhuang, XL

Chen, XS ^{[1
]}

Cao, T

机构：

[1] Shanghai Univ, Dept Polymer Mat, Shanghai 201800, Peoples R China

[2] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2005年 / 26卷 / 06期

关键词：

5-fluorouracil; poly (lactic acide) (PLA); poly(lactic acid)-polyethylene glycol (PLA-PEG); microspheres; nano-silica; controlled drug-release;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Microspheres containing an antimetabolite drug 5-Fluorouracil were prepared from poly(lactic acide) (PLA) or poly (lactic acid)-polyethylene glycol (PLA-PEG) as the carrier by using a water-in-oil-in-water emulsion solvent evaporation technique. The conditions of the microspheres preparation such as Poly- mer concentration in organic solvent, relative molecular weight of PLA-PEG and PLA/PEG mass ratio were discussed. The surface morphology and the size of the microspheres were observed by SEM. The drug content of microspheres was examined by TGA and the drug release in vitro was evaluated. According to the results, the drug content increased with the nano-silica used. The highest drug content in this study was 39.9%. The drug-release kinetics satisfied the requirements of controlled drug-release.

引用

页码：1174 / 1176

页数：3

共 12 条

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