Frequency distribution, genotypes and prevalent sequence types of New Delhi metallo-β-lactamase-producing Escherichia coli among clinical isolates around the world: A review

Objectives: New Delhi metallo-beta-lactamase (NDM)-producing Escherichia coli is perceived as one of the primary multidrug-resistant bacteria causing infections in hospitals and clinics. In this review, we present the frequency distribution, genotypes and most prevalent sequence types (STs) of NDM-producing E. coli among clinical isolates worldwide. Methods: Several international databases, including Medline, Embase, Scopus and Web of Science, were searched from 2008 to 2018 to identify studies addressing the prevalence of NDM-producing E. coli around the world. Results: Of 974 records identified from the databases, 110 studies fulfilled the eligibility criteria and were included in this analysis. The prevalence of NDM-producing E. coli was 82.6%, 12.9%, 1.5%, 1.0% and 2.0% in Asia, Europe, America, Africa and Oceania, respectively. The most common reported STs among NDM-producing E. coli were ST101, ST167, ST131, ST405, ST410 and ST648. Conclusion: The spread of NDM variants among E. coli strains is a serious threat to global public health. In addition, the most prevalent E. coli clonal groups, such as ST101 and ST167, are one of the main causes of E. coli infection in different countries. (C) 2019 International Society for Antimicrobial Chemotherapy. Published by Elsevier Ltd. All rights