Solid-Phase Synthesis of γ-AApeptides Using a Submonomeric Approach

被引：17

作者：

Wu, Haifan ^{[1
]}

Amin, Mohamed Nassir ^{[1
]}

Niu, Youhong ^{[1
]}

Qiao, Qiao ^{[1
]}

Harfouch, Nassier ^{[1
]}

Nimer, Abdelfattah ^{[1
]}

Cai, Jianfeng ^{[1
]}

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 13期

关键词：

BETA-PEPTIDES; COMBINATORIAL LIBRARIES; UNNATURAL BIOPOLYMERS; PROTEIN LIGANDS; PEPTOIDS; IDENTIFICATION; FOLDAMERS; BINDING; PEPTIDOMIMETICS; INHIBITOR;

D O I：

10.1021/ol301406a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The solid-phase synthesis of gamma-AApeptides using a novel submonomeric approach that utilizes an allyl protection is reported. The strategy successfully circumvents the necessity of preparing gamma-AApeptide building blocks in order to prepare gamma-AApeptide sequences. This method will maximize the potential of developing chemically diverse gamma-AApeptide libraries and thereby facilitate the biological applications of gamma-AApeptides in the future.

引用

页码：3446 / 3449

页数：4

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