Absolute cerebral blood flow quantification with pulsed arterial spin labeling during hyperoxia corrected with the simultaneous measurement of the longitudinal relaxation time of arterial blood
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作者:
Pilkinton, David T.
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Univ Penn, Stellar Chance Labs B1, Dept Biochem & Biophys, Philadelphia, PA 19104 USA
Univ Penn, Dept Radiol, CMROI, Philadelphia, PA 19104 USAUniv Penn, Stellar Chance Labs B1, Dept Biochem & Biophys, Philadelphia, PA 19104 USA
Pilkinton, David T.
[1
,2
]
Hiraki, Teruyuki
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Univ Penn, Dept Neurol, Philadelphia, PA 19104 USAUniv Penn, Stellar Chance Labs B1, Dept Biochem & Biophys, Philadelphia, PA 19104 USA
Hiraki, Teruyuki
[3
]
Detre, John A.
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Univ Penn, Dept Radiol, CMROI, Philadelphia, PA 19104 USA
Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA
Univ Penn, Dept Radiol, Ctr Funct Neuroimaging, Philadelphia, PA 19104 USAUniv Penn, Stellar Chance Labs B1, Dept Biochem & Biophys, Philadelphia, PA 19104 USA
Detre, John A.
[2
,3
,4
]
Greenberg, Joel H.
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Univ Penn, Dept Neurol, Philadelphia, PA 19104 USAUniv Penn, Stellar Chance Labs B1, Dept Biochem & Biophys, Philadelphia, PA 19104 USA
Greenberg, Joel H.
[3
]
Reddy, Ravinder
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Univ Penn, Dept Radiol, CMROI, Philadelphia, PA 19104 USAUniv Penn, Stellar Chance Labs B1, Dept Biochem & Biophys, Philadelphia, PA 19104 USA
Reddy, Ravinder
[2
]
机构:
[1] Univ Penn, Stellar Chance Labs B1, Dept Biochem & Biophys, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Radiol, CMROI, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA
[4] Univ Penn, Dept Radiol, Ctr Funct Neuroimaging, Philadelphia, PA 19104 USA
Quantitative arterial spin labeling (ASL) estimates of cerebral blood flow (CBF) during oxygen inhalation are important in several contexts, including functional experiments calibrated with hyperoxia and studies investigating the effect of hyperoxia on regional CBF. However, ASL measurements of CBF during hyperoxia are confounded by the reduction in the longitudinal relaxation time of arterial blood (T1a) from paramagnetic molecular oxygen dissolved in blood plasma. The aim of this study is to accurately quantify the effect of arbitrary levels of hyperoxia on T1a and correct ASL measurements of CBF during hyperoxia on a per-subject basis. To mitigate artifacts, including the inflow of fresh spins, partial voluming, pulsatility, and motion, a pulsed ASL approach was implemented for in vivo measurements of T1a in the rat brain at 3 Tesla. After accounting for the effect of deoxyhemoglobin dilution, the relaxivity of oxygen on blood was found to closely match phantom measurements. The results of this study suggest that the measured ASL signal changes are dominated by reductions in T1a for brief hyperoxic inhalation epochs, while the physiologic effects of oxygen on the vasculature account for most of the measured reduction in CBF for longer hyperoxic exposures. Magn Reson Med, 2011. (c) 2011 Wiley-Liss, Inc.
机构:
Univ Fukui, Dept Radiol, Fac Med Sci, 23-3 Matsuoka Shimoaizuki, Fukui 9101193, JapanUniv Fukui, Dept Radiol, Fac Med Sci, 23-3 Matsuoka Shimoaizuki, Fukui 9101193, Japan
Shimizu, Kazuhiro
Kosaka, Nobuyuki
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Univ Fukui, Dept Radiol, Fac Med Sci, 23-3 Matsuoka Shimoaizuki, Fukui 9101193, JapanUniv Fukui, Dept Radiol, Fac Med Sci, 23-3 Matsuoka Shimoaizuki, Fukui 9101193, Japan
Kosaka, Nobuyuki
Fujiwara, Yasuhiro
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Univ Fukui Hosp, Radiol Ctr, Fukui, Japan
Kumamoto Univ, Fac Life Sci, Kumamoto, JapanUniv Fukui, Dept Radiol, Fac Med Sci, 23-3 Matsuoka Shimoaizuki, Fukui 9101193, Japan
Fujiwara, Yasuhiro
Matsuda, Tsuyoshi
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GE Healthcare Japan Corp, Global MR Applicat & Workflow, Tokyo, JapanUniv Fukui, Dept Radiol, Fac Med Sci, 23-3 Matsuoka Shimoaizuki, Fukui 9101193, Japan
Matsuda, Tsuyoshi
Yamamoto, Tatsuya
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Univ Fukui, Dept Radiol, Fac Med Sci, 23-3 Matsuoka Shimoaizuki, Fukui 9101193, JapanUniv Fukui, Dept Radiol, Fac Med Sci, 23-3 Matsuoka Shimoaizuki, Fukui 9101193, Japan
Yamamoto, Tatsuya
Tsuchida, Tatsuro
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Univ Fukui, Dept Radiol, Fac Med Sci, 23-3 Matsuoka Shimoaizuki, Fukui 9101193, JapanUniv Fukui, Dept Radiol, Fac Med Sci, 23-3 Matsuoka Shimoaizuki, Fukui 9101193, Japan
Tsuchida, Tatsuro
Tsuchiyama, Katsuki
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Univ Fukui, Fac Med Sci, Dept Urol, Fukui, JapanUniv Fukui, Dept Radiol, Fac Med Sci, 23-3 Matsuoka Shimoaizuki, Fukui 9101193, Japan
Tsuchiyama, Katsuki
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Oyama, Nobuyuki
Kimura, Hirohiko
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Univ Fukui, Dept Radiol, Fac Med Sci, 23-3 Matsuoka Shimoaizuki, Fukui 9101193, JapanUniv Fukui, Dept Radiol, Fac Med Sci, 23-3 Matsuoka Shimoaizuki, Fukui 9101193, Japan
机构:
Kyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Higashi Ku, Fukuoka 8128582, JapanKyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Higashi Ku, Fukuoka 8128582, Japan
Yoshiura, T.
Hiwatashi, A.
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机构:Kyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Higashi Ku, Fukuoka 8128582, Japan
Hiwatashi, A.
Yamashita, K.
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机构:Kyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Higashi Ku, Fukuoka 8128582, Japan
Yamashita, K.
Ohyagi, Y.
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Kyushu Univ, Grad Sch Med Sci, Dept Neurol, Fukuoka 8128582, JapanKyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Higashi Ku, Fukuoka 8128582, Japan
Ohyagi, Y.
Monji, A.
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Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiat, Fukuoka 8128582, JapanKyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Higashi Ku, Fukuoka 8128582, Japan
Monji, A.
Takayama, Y.
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机构:Kyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Higashi Ku, Fukuoka 8128582, Japan
Takayama, Y.
Nagao, E.
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机构:Kyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Higashi Ku, Fukuoka 8128582, Japan
Nagao, E.
Kamano, H.
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机构:Kyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Higashi Ku, Fukuoka 8128582, Japan
Kamano, H.
Noguchi, T.
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机构:Kyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Higashi Ku, Fukuoka 8128582, Japan
Noguchi, T.
Honda, H.
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机构:Kyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Higashi Ku, Fukuoka 8128582, Japan
机构:
SUNY Binghamton, Dept Comp Sci, Binghamton, NY 13902 USA
Beth Israel Deaconess Med Ctr, Dept Radiol, 330 Brookline Ave, Boston, MA 02215 USA
Harvard Med Sch, Boston, MA USASUNY Binghamton, Dept Comp Sci, Binghamton, NY 13902 USA
Dai, Weiying
Fong, Tamara
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机构:
Harvard Med Sch, Boston, MA USA
Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USASUNY Binghamton, Dept Comp Sci, Binghamton, NY 13902 USA
Fong, Tamara
Jones, Richard N.
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Brown Univ, Warren Alpert Med Sch, Dept Psychiat & Human Behav & Neurol, Providence, RI 02912 USASUNY Binghamton, Dept Comp Sci, Binghamton, NY 13902 USA
Jones, Richard N.
Marcantonio, Edward
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Harvard Med Sch, Boston, MA USA
Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USASUNY Binghamton, Dept Comp Sci, Binghamton, NY 13902 USA
Marcantonio, Edward
Schmitt, Eva
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Hebrew SeniorLife, Inst Aging Res, Boston, MA USASUNY Binghamton, Dept Comp Sci, Binghamton, NY 13902 USA
Schmitt, Eva
Inouye, Sharon K.
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Harvard Med Sch, Boston, MA USA
Hebrew SeniorLife, Inst Aging Res, Boston, MA USA
Beth Israel Deaconess Med Ctr, Dept Gerontol, Boston, MA 02215 USASUNY Binghamton, Dept Comp Sci, Binghamton, NY 13902 USA
Inouye, Sharon K.
Alsop, David C.
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机构:
Beth Israel Deaconess Med Ctr, Dept Radiol, 330 Brookline Ave, Boston, MA 02215 USA
Harvard Med Sch, Boston, MA USASUNY Binghamton, Dept Comp Sci, Binghamton, NY 13902 USA