Convenient One Pot Synthesis and Antibacterial Evaluation of Some New Mannich Bases Carrying 1,2,4-Triazolyl Moiety

被引：6
|
作者：
Arafa, Wael A. A. [1 ]
Mohamed, Asmaa S. [2 ]
机构：
[1] Fayoum Univ, Fac Sci, Dept Chem, Al Fayyum, Egypt
[2] Theodor Bilharz Res Inst, Dept Med Chem, Giza, Egypt
来源：
CHINESE JOURNAL OF CHEMISTRY | 2011年 / 29卷 / 08期
关键词：
bi-1,2,4-triazoles; Schiff bases; Mannich bases; regioselectivity; antibacterial activity; ANTIMICROBIAL ACTIVITY; DERIVATIVES; HETEROCYCLES;
D O I：
10.1002/cjoc.201180297
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of Mannich bases were synthesized by a three-component Mannich reaction. The newly synthesized compounds were well characterized by elemental analyses, IR, NMR and mass spectroscopic studies. The potential antibacterial effects of the synthesized compounds were investigated using standard bacterial strains: Gram-positive and Gram-negative bacteria. Interestingly, all the synthesized compounds were observed to be promising leads, possessing moderate to significant inhibitory activity as compared to standard.
引用
收藏
页码：1661 / 1668
页数：8
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