Utility of adult-based ultrasound malignancy risk stratifications in pediatric thyroid nodules

被引:62
|
作者
Martinez-Rios, Claudia [1 ,2 ,3 ]
Daneman, Alan [1 ,2 ]
Bajno, Lydia [1 ,2 ]
van der Kaay, Danielle C. M. [4 ,5 ]
Moineddin, Rahim [6 ]
Wasserman, Jonathan D. [4 ,7 ]
机构
[1] Hosp Sick Children, Dept Diagnost Imaging, Toronto, ON, Canada
[2] Univ Toronto, Dept Med Imaging, Toronto, ON, Canada
[3] Univ Ottawa, Childrens Hosp Eastern Ontario, Dept Med Imaging, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada
[4] Hosp Sick Children, Div Endocrinol, Toronto, ON, Canada
[5] Juliana Childrens Hosp, Haga Hosp, Div Pediat, The Hague, Netherlands
[6] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada
[7] Univ Toronto, Dept Pediat, Toronto, ON, Canada
关键词
American Thyroid Association; Children; Thyroid; Thyroid carcinoma; Thyroid Image Reporting and Data System; Ultrasound; ASSOCIATION MANAGEMENT GUIDELINES; CANCER-RISK; DATA SYSTEM; CHILDREN; FEATURES; BENIGN;
D O I
10.1007/s00247-017-3974-y
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Individual ultrasound (US) features have limited ability to distinguish benign from malignant thyroid nodules. Adult-based systems have been developed to integrate the sonographic features in an effort to improve diagnostic accuracy. None, however, has been validated in children, in whom the likelihood of malignancy is 2-5 times higher than adults. To assess the performance of two adult-based sonographic (US) stratification methods for assessment of thyroid nodules in children. This retrospective study comprised 124 children who underwent thyroid US. Three radiologists reviewed the US data using the American Thyroid Association (ATA) and the Thyroid Image Reporting and Data System (TI-RADS). Radiologists' accuracy and agreement was assessed. The reference standard was histopathology/cytology or 2-year follow-up of clinical outcome for nonoperative cases. We assessed 71 benign and 52 malignant nodules and excluded 1 nodule. Using the ATA pattern descriptions, 80% of malignant nodules were classified as "high" 36/52 (69%) or "intermediate" 6/52 (11%) likelihood of malignancy. A total of 20/71 (28%) benign nodules were also classified within these two categories. Using the TI-RADS, malignant nodules were classified as 2, 3, 4a, 4b, 4c and 5, with rate of malignancy of 0%, 0%, 7/52 (13.5%), 7/52 (13.5%), 32/52 (61.5%) and 6/52 (11.5%), respectively. Benign nodules were also classified in the 4a (26/71; 36.6%), 4b (17/71; 24%), 4c (14/71; 19.7%) and 5 (1/71; 1.4%) categories. The positive and negative predictive values were 68.0% and 87.5% for ATA, and 71.7% and 80.0% for TI-RADS. We validated the use of ATA and TI-RADS methods in children and showed that they have test characteristics similar to those in adults, although neither is independently sufficient to discriminate nodules' likelihood of malignancy.
引用
收藏
页码:74 / 84
页数:11
相关论文
共 50 条
  • [1] Utility of adult-based ultrasound malignancy risk stratifications in pediatric thyroid nodules
    Claudia Martinez-Rios
    Alan Daneman
    Lydia Bajno
    Danielle C. M. van der Kaay
    Rahim Moineddin
    Jonathan D. Wasserman
    Pediatric Radiology, 2018, 48 : 74 - 84
  • [2] Diagnostic Performance of Five Adult-based US Risk Stratification Systems in Pediatric Thyroid Nodules
    Kim, Pyeong Hwa
    Yoon, Hee Mang
    Baek, Jung Hwan
    Chung, Sae Rom
    Choi, Young Jun
    Lee, Jeong Hyun
    Lee, Jin Seong
    Jung, Ah Young
    Cho, Young Ah
    Bak, Boram
    Na, Dong Gyu
    RADIOLOGY, 2022, 305 (01) : 190 - 198
  • [3] Diagnostic performance of adult-based ultrasound risk stratification systems in pediatric thyroid nodules: a systematic review and meta-analysis
    Xing, Zhichao
    Qiu, Yuxuan
    Zhu, Jingqiang
    Su, Anping
    Wu, Wenshuang
    FRONTIERS IN ENDOCRINOLOGY, 2023, 14
  • [4] Risk for malignancy of thyroid nodules based on ultrasound imaging characteristics
    Wu, Qi
    Li, Juanjuan
    Wu, Juan
    Li, Xiang
    Chen, Chuang
    Jiang, Nan
    Sun, Shengrong
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016, 9 (06): : 11817 - 11823
  • [5] Pediatric Thyroid Nodules: Ultrasound Characteristics as Indicators of Malignancy
    Fornwalt, Brandon
    Melachuri, Manasa
    Kubina, Matthew
    McDaniel, Janice
    Jeyakumar, Anita
    OTO OPEN, 2022, 6 (01)
  • [6] The Utility of Contrast-Enhanced Ultrasound (CEUS) in Assessing the Risk of Malignancy in Thyroid Nodules
    Zylka, Agnieszka
    Dobruch-Sobczak, Katarzyna
    Piotrzkowska-Wroblewska, Hanna
    Jedrzejczyk, Maciej
    Bakula-Zalewska, Elwira
    Goralski, Piotr
    Galczynski, Jacek
    Dedecjus, Marek
    CANCERS, 2024, 16 (10)
  • [7] Diagnostic performance of adult-based ATA and ACR-TIRADS ultrasound risk stratification systems in pediatric thyroid nodules: a systematic review and meta-analysis
    Pyeong Hwa Kim
    Hee Mang Yoon
    Jisun Hwang
    Jin Seong Lee
    Ah Young Jung
    Young Ah Cho
    Jung Hwan Baek
    European Radiology, 2021, 31 : 7450 - 7463
  • [8] Clinic-Based Ultrasound Can Predict Malignancy in Pediatric Thyroid Nodules
    Goldfarb, Melanie
    Gondek, Stephan S.
    Sanchez, Yamile
    Lew, John I.
    THYROID, 2012, 22 (08) : 827 - 831
  • [9] Diagnostic performance of adult-based ATA and ACR-TIRADS ultrasound risk stratification systems in pediatric thyroid nodules: a systematic review and meta-analysis
    Kim, Pyeong Hwa
    Yoon, Hee Mang
    Hwang, Jisun
    Lee, Jin Seong
    Jung, Ah Young
    Cho, Young Ah
    Baek, Jung Hwan
    EUROPEAN RADIOLOGY, 2021, 31 (10) : 7450 - 7463
  • [10] Systems of RISK Stratification of Malignancy by Ultrasound of Thyroid Nodules
    Rodriguez Arrieta, Luis Antonio
    Roman-Gonzalez, Alejandro
    Builes Barrera, Carlos A.
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2020, 12 (11)