Zidovudine genotypic resistance in HIV-1-infected newborns in the French Perinatal Cohort

被引：0
|
作者：
Masquelier, B
Chaix, ML
Burgard, M
Lechenadec, J
Doussin, A
Simon, F
Cottalorda, J
Izopet, J
Tamalet, C
Douard, D
Fleury, H
Mayaux, MJ
Blanche, S
Rouzioux, C
机构：
[1] Ctr Hosp Univ Necker Paris, Virol Lab, Paris, France
[2] Ctr Hosp Univ Kremlin Bicetre, INSERM U292, Virol Lab, Le Kremlin Bicetre, France
[3] Ctr Hosp Univ Bichat Paris, Virol Lab, Paris, France
[4] Ctr Hosp Univ Nice, Virol Lab, Nice, France
[5] Ctr Hosp Univ Toulouse, Virol Lab, Toulouse, France
[6] Ctr Hosp Univ Marseille, Virol Lab, Marseille, France
[7] Hop Pellegrin, Serv Pediat, Bordeaux, France
[8] Hop Necker Enfants Malad, Serv Pediat, Paris, France
[9] Ctr Hosp Univ Bordeaux, Hop Pellegrin, Virol Lab, F-33076 Bordeaux, France
来源：
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2001年 / 27卷 / 02期
关键词：
HIV-1 mother-child transmission; zidovudine; drug resistance; AJ276519; AJ276552; variability;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A retrospective study was set up to investigate the frequency of zidovudine (ZDV)-resistant HIV-1 in infected newborns after ZDV prophylaxis in the French Perinatal Cohort study. Nucleotide sequence analysis was carried out from 34 infants' isolates and 18 maternal plasma samples. Mutations related to ZDV resistance were found in the HIV-1 reverse transcriptase in 7 of 34 children (20%). Evidence of mother-child transmission of ZDV-resistant HIV-1 was found in 4 cases. Phylogenetic analysis showed that 14 of 34 HIV-1 isolates from the infants belonged to non-B subtypes. The presence of ZDV resistance-encoding mutations in the newborn isolates was associated with a longer total duration of exposure to ZDV. In a context of a wide HIV-1 variability, ZDV resistance can be one of the factors contributing to mother-child transmission.
引用
收藏
页码：99 / 104
页数：6
相关论文
共 50 条
  • [1] Prevalence of genotypic drug resistance among a cohort of HIV-infected newborns
    Parker, MM
    Wade, N
    Lloyd, RM
    Birkhead, GS
    Gallagher, BK
    Cheku, B
    Sullivan, T
    Taylor, J
    [J]. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2003, 32 (03) : 292 - 297
  • [2] INVIVO COMPARISON OF ZIDOVUDINE RESISTANCE IN BLOOD AND CSF OF HIV-1-INFECTED PATIENTS
    WILDEMANN, B
    HAAS, J
    EHRHART, K
    HAHN, M
    WAGNER, H
    STORCHHAGENLOCHER, B
    [J]. NEUROLOGY, 1993, 43 (04) : A266 - A266
  • [3] Presence of genotypic resistance to antiretroviral drugs in a cohort of therapy-naive HIV-1-infected Italian patients
    Re, MC
    Monari, P
    Borderi, M
    Tadolini, M
    Verucchi, G
    Vitone, F
    Spinosa, S
    La Placa, M
    [J]. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2001, 27 (03) : 315 - 316
  • [4] Diversity and prevalence of antiretroviral genotypic resistance mutations among HIV-1-infected children
    Almeida, Flavia J.
    Berezin, Eitan N.
    Rodrigues, Rosangela
    Safadi, Marco A. P.
    Arnoni, Mariana V.
    Oliveira, Cristina
    Brigido, Luis F. M.
    [J]. JORNAL DE PEDIATRIA, 2009, 85 (02) : 104 - 109
  • [5] Genotypic resistance and immunologic outcomes among HIV-1-infected women with viral failure
    Gange, SJ
    Schneider, MF
    Grant, RM
    Liegler, T
    French, A
    Young, M
    Anastos, K
    Wilson, TE
    Ponath, C
    Greenblatt, R
    [J]. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2006, 41 (01) : 68 - 74
  • [6] Emergence of dual resistance to zidovudine and lamivudine in HIV-1-infected patients treated with zidovudine plus lamivudine as initial therapy
    Kuritzkes, DR
    Shugarts, D
    Bakhtiari, M
    Poticha, D
    Johnson, J
    Rubin, M
    Gingeras, TR
    Kennedy, M
    Eron, JJ
    [J]. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2000, 23 (01) : 26 - 34
  • [7] EMERGENCE AND CLINICAL RELEVANCE OF MUTATIONS ASSOCIATED WITH ZIDOVUDINE RESISTANCE IN ASYMPTOMATIC HIV-1-INFECTED PATIENTS
    CALDERON, EJ
    TORRES, Y
    MEDRANO, FJ
    LUQUE, F
    LARDER, B
    REY, C
    SANCHEZOUIJANO, A
    LISSEN, E
    LEAL, M
    [J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1995, 14 (06) : 512 - 519
  • [8] IN-VIVO COMPARISON OF ZIDOVUDINE RESISTANCE MUTATIONS IN BLOOD AND CSF OF HIV-1-INFECTED PATIENTS
    WILDEMANN, B
    HAAS, J
    EHRHART, K
    HAHN, M
    WAGNER, H
    LYNEN, N
    STORCHHAGENLOCHER, B
    [J]. NEUROLOGY, 1993, 43 (12) : 2659 - 2663
  • [9] Perinatal HIV-1 transmission -: Interaction between zidovudine prophylaxis and mode of delivery in the French Perinatal Cohort
    Mandelbrot, L
    Le Chenadec, J
    Berrebi, A
    Bongain, M
    Bénifla, JL
    Delfraissy, JF
    Blanche, S
    Mayaux, MJ
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (01): : 55 - 60
  • [10] Low frequency of genotypic resistance in HIV-1-infected patients failing an atazanavir-containing regimen: a clinical cohort study
    Dolling, David I.
    Dunn, David T.
    Sutherland, Katherine A.
    Pillay, Deenan
    Mbisa, Jean L.
    Parry, Chris M.
    Post, Frank A.
    Sabin, Caroline A.
    Cane, Patricia A.
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2013, 68 (10) : 2339 - 2343
12345