KL-6 as a biomarker of respiratory complications in severely disabled children

被引：3

作者：

Ochi, Fumihiro ^{[1
,3
,4
]}

Fukuda, Mitsumasa ^{[1
]}

Ohmori, Hiromitsu ^{[3
,5
]}

Yano, Yoshiaki ^{[4
]}

Wakamoto, Hiroyuki ^{[2
]}

Suzuki, Yuka ^{[1
,2
]}

Ishii, Eiichi ^{[1
]}

机构：

[1] Ehime Univ, Grad Sch Med, Dept Pediat, Toon, Ehime 7910295, Japan

[2] Ehime Rehabil Ctr Children, Dept Pediat, Toon, Japan

[3] Ehime Prefectural Cent Hosp, Dept Pediat, Matsuyama, Ehime, Japan

[4] Sumitomobesshi Hosp, Dept Pediat, Niihama, Japan

[5] Natl Hosp Org Yanai Med Ctr, Dept Pediat, Yamaguchi, Japan

来源：

PEDIATRICS INTERNATIONAL | 2015年 / 57卷 / 03期

关键词：

computed tomography; KL-6; respiratory infection; respiratory problem; severe motor and intellectual disabilities; INTELLECTUAL DISABILITIES; SEVERE MOTOR; CT FINDINGS; PNEUMONIA; ASPIRATION;

D O I：

10.1111/ped.12537

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

BackgroundThe aim of this study was to assess the importance of KL-6 level in evaluating the status of stabilized chronic pneumonia in children in the severe motor and intellectual disabilities-medical care-dependent (SMID-MCD) category. MethodsA total of 20 SMID-MCD children were enrolled in this study. Serum KL-6, white blood cell count, C-reactive protein, chest computed tomography (CT) and other factors related to respiratory complications were analyzed in all children under stable respiratory conditions. ResultsMean age was 5.8 1.0years (mean +/- SE). Serum KL-6 was significantly higher in those SMID-MCD children with abnormal CT than in those with normal CT: 316 +/- 39U/mL versus 190 +/- 11, respectively (P = 0.0075). ConclusionsMeasures of serum KL-6 level provide valuable information for determining the respiratory management of SMID-MCD children with occult chronic pneumonia.

引用

页码：439 / 442

页数：4

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