Why Do Phase III Clinical Trials in Oncology Fail so Often?

被引：39
|
作者：
Amiri-Kordestani, Laleh [1 ]
Fojo, Tito [1 ]
机构：
[1] NCI, Med Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
来源：
JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2012年 / 104卷 / 08期
关键词：
DRUG DEVELOPMENT; TARGETED AGENTS; STABLE DISEASE; END-POINT; CHEMOTHERAPY; SURVIVAL; CANCER; BENEFIT; DESIGNS;
D O I：
10.1093/jnci/djs180
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：568 / 569
页数：2
相关论文
共 50 条
  • [1] Why do Phase III Clinical Trials in Oncology Fail so Often? (vol 104, pg 568, 2012)
    Amiri-Kordestani, Laleh
    Fojo, Tito
    JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2012, 104 (11) : 895 - 895
  • [2] Why do phase III trials of promising heart failure drugs often fail? The contribution of 'regression to the truth"
    Krum, H
    Tonkin, A
    JOURNAL OF CARDIAC FAILURE, 2003, 9 (05) : 364 - 367
  • [3] Why We Fail at Cancer Clinical Trials So Often: An Anesthesiologist's Perspective
    Hu, Jian
    ANESTHESIOLOGY, 2024, 140 (03) : 349 - 351
  • [4] Why do ERP projects fail so often in Iran?
    Nashirifard, P
    Nazemi, E
    8TH WORLD MULTI-CONFERENCE ON SYSTEMICS, CYBERNETICS, AND INFORMATICS, VOL XVI, PROCEEDINGS, 2004, : 466 - 468
  • [5] Why do clinical trials fail?
    Rickels, Karl
    Robinson, Donald S.
    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2007, 27 (04) : 420 - 421
  • [6] Uncertainty in the Translation of Preclinical Experiments to Clinical Trials. Why do Most Phase III Clinical Trials Fail?
    Lowenstein, Pedro R.
    Castro, Maria G.
    CURRENT GENE THERAPY, 2009, 9 (05) : 368 - 374
  • [7] Clinical trial research in focus: why do so many clinical trials fail in IPF?
    Spagnolo, Paolo
    Maher, Toby M.
    LANCET RESPIRATORY MEDICINE, 2017, 5 (05): : 372 - 374
  • [8] Why do so many clinical trials of therapies for Alzheimer's disease fail?
    Anderson, Roy M.
    Hadjichrysanthou, Christoforos
    Evans, Stephanie
    Wong, Mei Mei
    LANCET, 2017, 390 (10110): : 2327 - 2329
  • [9] Why Do So Many Nonalcoholic Steatohepatitis Trials Fail?
    Ratziu, Vlad
    Friedman, Scott L.
    GASTROENTEROLOGY, 2023, 165 (01) : 5 - 10
  • [10] Hospital checklists are meant to save lives - so why do they often fail?
    Anthes, Emily
    NATURE, 2015, 523 (7562) : 516 - 518
12345