A new near-infrared excitation PDT photosensitizer in vivo

被引：0
|
作者：
Feng Yueshu [1 ,2 ]
Li Binyu [3 ]
Huang Yulin [4 ]
机构：
[1] Jilin Engn Normal Univ, Inst Interdisciplinary Quantum Informat Technol, Changchun 130052, Peoples R China
[2] Jilin Engn Lab Quantum Informat Technol, Changchun 130052, Peoples R China
[3] Changchun Univ Sci & Technol, Changchun 130022, Peoples R China
[4] Tangshan Peoples Hosp, Tangshan 063001, Peoples R China
来源：
AOPC 2021: BIOMEDICAL OPTICS | 2021年 / 12067卷
关键词：
Photodynamic therapy; Fluorescence resonance energy transfer; CuInS2/ZnS QDs; Photosensitizer; PHOTODYNAMIC THERAPY PDT;
D O I：
10.1117/12.2606475
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Recently, near-infrared (NIR) excitation has been suggested for PDT improvement and therapy of cancer.In this study, 5-aminolevulinic acid (ALA), a kind of photosensitizer, were coordinated to CuInS2/ZnS QDs to form the CuInS2/ZnS-ALA conjugates. An efficient transfer of energy from the donor (QDs) to the acceptor (ALA) was demonstrated through forster resonance energy transfer (FRET). The treatment effects of the conjugates in vivo was confirmed under 1300nm femtosecond laser. The results demonstrate that the CuInS2/ZnS-ALA conjugates are promising for PDT and can be used in imaging and biomedical field.
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页数：6
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