Synthesis and structure-activity relationship of substituted tetrahydrofuroyl-1-phenylalanine derivatives as potent and selective VLA-4 antagonists.

被引：0
|
作者：
Doherty, GA
Yang, G
Borges, E
Chang, L
Truong, Q
Kopka, I
MacCoss, M
Tong, XC
Kidambi, U
Egger, LA
McCauley, E
Van Riper, G
Mumford, RA
Schmidt, JA
Hagmann, WK
机构：
[1] Merck & Co Inc, Merck Sharp & Dohme Res Labs, Dept Med Chem, Rahway, NJ 07065 USA
[2] Merck & Co Inc, Merck Sharp & Dohme Res Labs, Dept Immunol & Rheumatol, Rahway, NJ USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2001年 / 222卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
133-MEDI
引用
收藏
页码：U661 / U662
页数：2
相关论文
共 50 条
  • [1] Discovery of tetrahydrofuroyl-1-phenylalanine derivatives as potent VLA-4 antagonists.
    Yang, GXQ
    Doherty, GA
    Chang, LL
    deLaszlo, SE
    Li, B
    Magriotis, PA
    Truong, Q
    Hagmann, WK
    MacCoss, M
    Tong, XC
    Kidambi, U
    Egger, L
    McCauley, E
    Van Riper, G
    Schmidt, J
    Mumford, RA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 222 : U661 - U661
  • [2] Substituted tetrahydrofuroyl-1-phenylalanine derivatives as potent and specific VLA-4 antagonists
    Doherty, GA
    Yang, GX
    Borges, E
    Chang, LL
    MacCoss, M
    Tong, S
    Kidambi, U
    Egger, LA
    McCauley, E
    Van Riper, G
    Mumford, RA
    Schmidt, JA
    Hagmann, WK
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (11) : 1501 - 1505
  • [3] Synthesis and structure-activity relationship of novel phenylalanine derivatives as potent VLA-4 integrin antagonists
    Okuzumi, Tatsuya
    Makino, Shingo
    Sagi, Kazuyuki
    Chiba, Akira
    Satake, Yuko
    Suzuki, Nobuyasu
    Izawa, Hiroyuki
    Yoshimura, Toshihiko
    Murata, Masahiro
    Nakanishi, Eiji
    Tsuji, Takashi
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 575 - 575
  • [4] Synthesis and structure-activity relationship of novel VLA-4 antagonists.
    Ikegami, S
    Hoshina, Y
    Okuyama, A
    Fukui, H
    Inoguchi, K
    Fujimoto, K
    Maruyama, T
    Harada, T
    Nakamura, T
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 226 : U35 - U35
  • [5] N-tetrahydrofuroyl-(L)-phenylalanine derivatives as potent VLA-4 antagonists
    Yang, GX
    Chang, LL
    Truong, Q
    Doherty, GA
    Magriotis, PA
    de Laszlo, SE
    Li, B
    MacCoss, M
    Kidambi, U
    Egger, LA
    McCauley, E
    Van Riper, G
    Mumford, RA
    Schmidt, JA
    Hagmann, WK
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (11) : 1497 - 1500
  • [6] Novel urea derivatives that are highly potent VLA-4 antagonists.
    Kassir, JL
    Grabbe, VO
    Biediger, RJ
    Scott, IL
    Market, RV
    Raju, BG
    Lin, SQ
    Dupre, B
    Kogan, TP
    Chan, Q
    Yu, T
    Holland, GW
    Maxwell, DC
    Vanderslice, P
    West, H
    Decker, ER
    Bourgoyne, A
    Tilton, R
    Munsch, CL
    Dixon, RAF
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 220 : U568 - U568
  • [7] Synthesis and structure-activity relationship of the potent antagonists of VLA-1 integrin
    VanBrunt, Michael Pete
    Kasar, Ramesh
    Kolakowski, Gabrielle R.
    Jacobson, Irina C.
    Harris, Edith A. S.
    Sui, Li-ming
    Lupher, Mark L., Jr.
    Staunton, Donald S.
    Farouz, Francine
    Thorsett, Eugene D.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
  • [8] Synthesis and structure-activity relationship of ethenesulfonamide derivatives: Potent and orally active endothelin receptor antagonists.
    Harada, H
    Kazami, J
    Watanuki, S
    Tsuzuki, R
    Sudoh, K
    Tanaka, A
    Fujimori, A
    Tsukamoto, S
    Yanagisawa, I
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 221 : U10 - U10
  • [9] N-(3-phenylsulfonyl-3-piperidinoyl)-phenylalanine derivatives as potent, selective VLA-4 antagonists
    Gutteridge, CE
    de Laszlo, SE
    Kamenecka, TM
    McCauley, E
    van Riper, G
    Mumford, RA
    Kidambi, U
    Egger, LA
    Tong, S
    Hagmann, WK
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (05) : 885 - 890
  • [10] Synthetic study of VLA-4/VCAM-1 inhibitors: Synthesis and structure-activity relationship of piperazinylphenylalanine derivatives
    Saku, Osamu
    Ohta, Kiminori
    Arai, Eri
    Nomoto, Yuji
    Miura, Hiroko
    Nakamura, Hiroaki
    Fuse, Eiichi
    Nakasato, Yoshisuke
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (03) : 1053 - 1057
12345